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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Becn1tm1Smoc
targeted mutation 1, Shanghai Model Organisms Center
MGI:6715552
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Becn1tm1Smoc/Becn1tm1Smoc
Foxp3tm4(YFP/icre)Ayr/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:7645511
cn2
 		Becn1tm1Smoc/Becn1tm1Smoc
Zfp91tm1Smoc/Zfp91tm1Smoc
Foxp3tm4(YFP/icre)Ayr/Y 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:7645512


Genotype
MGI:7645511
cn1
Allelic
Composition		 Becn1tm1Smoc/Becn1tm1Smoc
Foxp3tm4(YFP/icre)Ayr/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Becn1tm1Smoc mutation (1 available); any Becn1 mutation (36 available)
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal regulatory T cell physiology ( J:306129 )
• stimulated T reg cells exhibit increased extracellular acidification rate indicating higher baseline and maximum glycolytic rates than wild-type T reg cells
• stimulated T reg cells show much lower Foxp3 expression but higher IFN-gamma expression

immune system
abnormal regulatory T cell physiology ( J:306129 )
• stimulated T reg cells exhibit increased extracellular acidification rate indicating higher baseline and maximum glycolytic rates than wild-type T reg cells
• stimulated T reg cells show much lower Foxp3 expression but higher IFN-gamma expression




Genotype
MGI:7645512
cn2
Allelic
Composition		 Becn1tm1Smoc/Becn1tm1Smoc
Zfp91tm1Smoc/Zfp91tm1Smoc
Foxp3tm4(YFP/icre)Ayr/Y
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Becn1tm1Smoc mutation (1 available); any Becn1 mutation (36 available)
Foxp3tm4(YFP/icre)Ayr mutation (2 available); any Foxp3 mutation (58 available)
Zfp91tm1Smoc mutation (0 available); any Zfp91 mutation (97 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal regulatory T cell physiology ( J:306129 )
• stimulated T reg cells exhibit higher baseline and maximum glycolytic rates than wild-type T reg cells but similar to either single conditional deletion mice
• stimulated T reg cells show much lower Foxp3 expression but higher IFN-gamma expression than wild-type T reg cells but similar to either single conditional deletion mice

immune system
abnormal regulatory T cell physiology ( J:306129 )
• stimulated T reg cells exhibit higher baseline and maximum glycolytic rates than wild-type T reg cells but similar to either single conditional deletion mice
• stimulated T reg cells show much lower Foxp3 expression but higher IFN-gamma expression than wild-type T reg cells but similar to either single conditional deletion mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory