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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rac3tm1.1Bea
targeted mutation 1.1, The Beatson Institute for Cancer Research
MGI:6715570
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Apctm1Tno/Apc+
Rac3tm1.1Bea/Rac3tm1.1Bea
Tg(Vil1-cre/ERT2)23Syr/0 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 MGI:6715667


Genotype
MGI:6715667
cn1
Allelic
Composition		 Apctm1Tno/Apc+
Rac3tm1.1Bea/Rac3tm1.1Bea
Tg(Vil1-cre/ERT2)23Syr/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1Tno mutation (6 available); any Apc mutation (158 available)
Rac3tm1.1Bea mutation (0 available); any Rac3 mutation (13 available)
Tg(Vil1-cre/ERT2)23Syr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
decreased alimentary system tumor incidence ( J:306088 )
• reduced number of intestinal tumors in duodenum and jejunum
• normal number of intestinal tumors in ileum and colon
decreased intestinal adenoma incidence ( J:306088 )
• reduced number of intestinal tumors in duodenum and jejunum

neoplasm
decreased tumor growth/size ( J:306088 )
• tumors less proliferative
• reduced ability to form colonies from single tumor cells in vitro
abnormal tumor susceptibility ( J:306088 )
• median intestinal tumor-free survival 138 vs 171 days
decreased alimentary system tumor incidence ( J:306088 )
• reduced number of intestinal tumors in duodenum and jejunum
• normal number of intestinal tumors in ileum and colon
decreased intestinal adenoma incidence ( J:306088 )
• reduced number of intestinal tumors in duodenum and jejunum




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory