Analysis Tools|
Allele Symbol Allele Name Allele ID |
Elp2em3Bjw endonuclease-mediated mutation 3, Brandon J Wainwright MGI:6715581 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than the expected numbers are seen at 9-10 dpc and no mutants are obtained at 14-15 dpc
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• embryos are smaller at E10.5
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• embryos are smaller at E10.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than the expected numbers are seen at 9-10 dpc and no mutants are seen at 14-15 dpc
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• E9.5 embryos are smaller
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• E9.5 embryos are smaller
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• fewer than the expected numbers start to be seen at 16-17 dpc and 18.5 dpc, with no pups seen at weaning
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• fetuses are smaller at E14.5, E16.5, and E18.5
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• hemorrhaging is seen at 16.5 dpc and 18.5 dpc
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lifespan is to P60
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• brain to body weight ratio is decreased, indicating microcephaly
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• mice show an increase in self-grooming time and number of self-grooming bouts
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• mice exhibit motor defects
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• mice exhibit reduced number and duration of ultrasonic calls
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• Purkinje neuron degeneration in the cerebella
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• cerebellar atrophy
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autism spectrum disorder | DOID:0060041 | J:306113 | ||
| intellectual disability | DOID:1059 | J:306113 | ||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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