Phenotypes associated with this allele

• Allele Symbol: Sros1^em1Caox
• Allele Name: endonuclease-mediated mutation 1, Xuetao Cao
• Allele ID: MGI:6715665
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sros1^em1Caox/Sros1^em1Caox	involves: C57BL/6J	MGI:6715682

Genotype
MGI:6715682

hm1

• Allelic Composition: Sros1^em1Caox/Sros1^em1Caox
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:306407 )

• mice infected with L. monocytoges survive longer when challenged with a lethal dose, with 85% of mice surviving until day 10 compared to 77.5% of wild-type mice dying within 7 days after infection

immune system

abnormal circulating chemokine level ( J:306407 )

• serum chemokine ligands CXCL9, CXCL3, and CXCL10 are increased in L. monocytoges-infected mice

increased circulating CXCL10 level ( J:306407 )

• in L.monocytoges-infected mice

decreased susceptibility to bacterial infection ( J:306407 )

• mice show decreased susceptibility to Listeria monocytoges infection, with lower bacterial burdens in the spleen, liver, and lung 36 hours post infection and attenuated inflammatory cell infiltration and tissue damage in the lungs and spleen

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:306407 )

• mice infected with L. monocytoges survive longer when challenged with a lethal dose, with 85% of mice surviving until day 10 compared to 77.5% of wild-type mice dying within 7 days after infection

homeostasis/metabolism

abnormal circulating chemokine level ( J:306407 )

• serum chemokine ligands CXCL9, CXCL3, and CXCL10 are increased in L. monocytoges-infected mice

increased circulating CXCL10 level ( J:306407 )

• in L.monocytoges-infected mice