Phenotypes associated with this allele

• Allele Symbol: Hnf1b^tm2Ics
• Allele Name: targeted mutation 2, Mouse Clinical Institute
• Allele ID: MGI:6716050
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hnf1b^tm2Ics/Hnf1b^+	involves: 129 * C57BL/6N	MGI:6716064

Genotype
MGI:6716064

ht1

• Allelic Composition: Hnf1b^tm2Ics/Hnf1b⁺
• Genetic Background: involves: 129 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

decreased pancreatic acinar cell number ( J:306082 )

• at age 3 months

pancreatic acinar hypoplasia ( J:306082 )

• few acinar lobules

abnormal pancreatic duct morphology ( J:306082 )

• shorter primary cilia on ductal cells at age 3 months

endocrine/exocrine glands

decreased pancreatic acinar cell number ( J:306082 )

• at age 3 months

pancreatic acinar hypoplasia ( J:306082 )

• few acinar lobules

abnormal pancreatic duct morphology ( J:306082 )

• shorter primary cilia on ductal cells at age 3 months

decreased pancreatic islet number ( J:306082 )

• 20% reduction of total islet volume

• 28% reduction of total large islet volume

• 22% reduction in number of large islets

small pancreatic islets ( J:306082 )

• reduction in individual large islet volume

• 20% reduction of total islet volume

• 28% reduction of total large islet volume

pancreas fibrosis ( J:306082 )

pancreas lipomatosis ( J:306082 )

pancreatic acinar-to-ductal metaplasia ( J:306082 )

decreased insulin secretion ( J:306082 )

• 65% reduction in pancreatic insulin levels

• normal glucose-stimulated insulin secretion by isolated islets in vitro

chronic pancreas inflammation ( J:306082 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:306082 )

N • normal peripheral insulin sensitivity in insulin tolerance test (ITT) at age 24 weeks

decreased insulin secretion ( J:306082 )

• 65% reduction in pancreatic insulin levels

• normal glucose-stimulated insulin secretion by isolated islets in vitro

increased fasting circulating glucose level ( J:306082 )

hyperglycemia ( J:306082 )

decreased circulating insulin level ( J:306082 )

• at age 12 weeks

impaired glucose tolerance ( J:306082 )

• higher blood glucose levels in the intraperitoneal glucose tolerance tests (IPGTT)

immune system

chronic pancreas inflammation ( J:306082 )