mortality/aging
• mice die a few days after birth
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endocrine/exocrine glands
• defective polarity and organization
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• at E18.5
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• at E18.5
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• at E18.5
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• at E18.5
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• impaired in E18.5 embryos with reduced insulin, glucagon, somatostatin and pancreatic polypeptide-positive cell
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digestive/alimentary system
• defective polarity and organization
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