Phenotypes associated with this allele

• Allele Symbol: Trim10^em2Cya
• Allele Name: endonuclease-mediated mutation 2, Cyagen Biosciences
• Allele ID: MGI:6717383
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trim10^em2Cya/Trim10^em2Cya	Not Specified	MGI:6717405

Genotype
MGI:6717405

hm1

• Allelic Composition: Trim10^em2Cya/Trim10^em2Cya
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased response of heart to induced stress ( J:306658 )

• mice subjected to transverse aortic constriction (TAC) do not show an increase in cardiac pump function, with no increase in % fractional shortening of % ejection fraction as seen in wild-type mice

• mice show decreased TAC-induced hypertrophic responses, such as heart/bodyweight ratio, heart weight/tibia length ratio, myocyte size, and expression of hypertrophic markers indicating alleviation of TAC-induced cardiac hypertrophy

• mice show alleviation of TAC-induced increases in fibrotic area

homeostasis/metabolism

decreased response of heart to induced stress ( J:306658 )

• mice subjected to transverse aortic constriction (TAC) do not show an increase in cardiac pump function, with no increase in % fractional shortening of % ejection fraction as seen in wild-type mice

• mice show decreased TAC-induced hypertrophic responses, such as heart/bodyweight ratio, heart weight/tibia length ratio, myocyte size, and expression of hypertrophic markers indicating alleviation of TAC-induced cardiac hypertrophy

• mice show alleviation of TAC-induced increases in fibrotic area