Analysis Tools
neoplasm
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• injected B16F10 tumor model in tamoxifen-treated mice
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Allele Symbol Allele Name Allele ID |
Pgdtm1.1Pse targeted mutation 1.1, Pankaj Seth MGI:6718292 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• injected B16F10 tumor model in tamoxifen-treated mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• shorter than normal lifespans
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• crusting ears
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• increased CD4/CD8 positive in the spleen
• increased frequencies of CD44high increased CD62Llow effector/memory T cells with reduced CD44low CD62Lhigh
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• increased Th1, Th2, and Th17 responses.
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• reduced Tregs suppressive function
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• significant Th2 (allergic) responses in the lung and spleen with increased collagen deposits
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• from CD4+ and CD8+ T cells
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• crusting eyelids
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• crusting ears
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• crusting eyelids
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• increased CD4/CD8 positive in the spleen
• increased frequencies of CD44high increased CD62Llow effector/memory T cells with reduced CD44low CD62Lhigh
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• increased Th1, Th2, and Th17 responses.
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• reduced Tregs suppressive function
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• activation of CD8+ T cells results in a more robust development of T effector cells
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• CD4+ and CD8+ T cells in the spleen and lymph nodes exhibit an altered immune phenotype, characterized by elevated CD44high/CD62Llow, KLRG1high/CD127low subsets and increased expression of CD69 activation marker
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• the frequency of CD4+ T cells in the lymph nodes and spleen is reduced
• mice have decreased absolute numbers of CD4+ T cells in secondary lymphoid organs
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• CD8+ T cells have a molecular signature of T effector cells in response to activation with anti-CD3 and anti-CD28 mAbs
• CD8+T cells show a large accumulation of glycogen accompanied by an increase in UDP-glucose, the direct substrate for glycogen synthesis
• activated CD8+ T cells have higher mitochondria number per cell than activated control cells and exhibit altered mitochondria morphology with wider cristae and less tightly organized intermembrane space, a pattern seen in effector T cells
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• the frequency of CD8+ T cells in the lymph nodes and spleen is reduced
• mice have decreased absolute numbers of CD8+ T cells in secondary lymphoid organs
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• CD8+ T cells exhibit enhanced glucose uptake capacity
• CD8+ T cells exhibit elevated mitochondrial membrane potential and enhanced mitochondrial respiration
• CD8+ T cells show higher reactive oxygen species (ROS) content and mitochondrial ROS production after stimulation than control cells
• examination of mitochondrial fission proteins indicates that mitochondria fission machinery is hyperactivated in in stimulated CD8+ T cells
• CD8+ T cells show an elevated level of lipid peroxidation after stimulation
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• activation of CD8+ T cells results in a more robust development of T effector cells
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• CD4+ and CD8+ T cells in the spleen and lymph nodes exhibit an altered immune phenotype, characterized by elevated CD44high/CD62Llow, KLRG1high/CD127low subsets and increased expression of CD69 activation marker
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• the frequency of CD4+ T cells in the lymph nodes and spleen is reduced
• mice have decreased absolute numbers of CD4+ T cells in secondary lymphoid organs
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• CD8+T cells show a large accumulation of glycogen accompanied by an increase in UDP-glucose, the direct substrate for glycogen synthesis
• CD8+ T cells have a molecular signature of T effector cells in response to activation with anti-CD3 and anti-CD28 mAbs
• activated CD8+ T cells have higher mitochondria number per cell than activated control cells and exhibit altered mitochondria morphology with wider cristae and less tightly organized intermembrane space, a pattern seen in effector T cells
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• the frequency of CD8+ T cells in the lymph nodes and spleen is reduced
• mice have decreased absolute numbers of CD8+ T cells in secondary lymphoid organs
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• CD8+ T cells exhibit enhanced glucose uptake capacity
• CD8+ T cells exhibit elevated mitochondrial membrane potential and enhanced mitochondrial respiration
• CD8+ T cells show higher reactive oxygen species (ROS) content and mitochondrial ROS production after stimulation than control cells
• examination of mitochondrial fission proteins indicates that mitochondria fission machinery is hyperactivated in in stimulated CD8+ T cells
• CD8+ T cells show an elevated level of lipid peroxidation after stimulation
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• CD8+T cells show a large accumulation of glycogen accompanied by an increase in UDP-glucose, the direct substrate for glycogen synthesis
• naive CD8+ T cells stimulated with anti-CD3 and anti-CD28 mAbs and IL-2 show glycogen buildup
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• CD8+ T cells isolated from mutant mice show higher cytotoxic function when co-cultured with EG7 tumor cells in vitro
• congenic (CD45.1+) mice implanted with EG7 tumor cells followed by adoptive transfer of CD8+ T cells from mutant mice show smaller tumors that recipients of control T cells, indicating that antigen-specific T cells have more potent anti-tumor effector function
• recipients of mutant T cells are able to clear a Listeria monocytogenes-Ova infection more effectively than control mice
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• CD8+ T cells isolated from mutant mice show higher cytotoxic function when co-cultured with EG7 tumor cells in vitro
• congenic (CD45.1+) mice implanted with EG7 tumor cells followed by adoptive transfer of CD8+ T cells from mutant mice show smaller tumors that recipients of control T cells, indicating that antigen-specific T cells have more potent anti-tumor effector function
• recipients of mutant T cells are able to clear a Listeria monocytogenes-Ova infection more effectively than control mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• CD8+ T cells co-cultured with B16-F10 melanoma cells uptake glucose more effectively than control cells
• adaptive transfer of mutant CD8+ T cells to congenic recipients bearing the B16-F10 melanoma results in smaller tumor growth than in controls
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• CD8+ T cells co-cultured with B16-F10 melanoma cells uptake glucose more effectively than control cells
• adaptive transfer of mutant CD8+ T cells to congenic recipients bearing the B16-F10 melanoma results in smaller tumor growth than in controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 06/12/2024 MGI 6.13 |
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