Phenotypes associated with this allele

• Allele Symbol: Uqcc3^em1Hya
• Allele Name: endonuclease-mediated mutation 1, Hanshuo Yang
• Allele ID: MGI:6718325
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Uqcc3^em1Hya/Uqcc3^em1Hya Speer6-ps1^Tg(Alb-cre)21Mgn/Speer6-ps1^+	involves: C57BL/6 * DBA/2	MGI:6718327

Genotype
MGI:6718327

cn1

• Allelic Composition: Uqcc3^em1Hya/Uqcc3^em1Hya; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased incidence of induced tumors ( J:306534 )

• hypdrodynamic transfection via tail-vein injection of oncogenes myr-AKT and NRasV12 results in barely presented tumor nodules on the liver surface and normal hepatocytes and stromal cells compared to excessive nodular lesions in controls

• mice show increased survival following hypdrodynamic transfection via tail-vein injection of oncogenes myr-AKT and NRasV12 compared to controls

• liver tumor tissues show a reduction in ATP following hypdrodynamic transfection via tail-vein injection of oncogenes myr-AKT and NRasV12

homeostasis/metabolism

abnormal physiological response to hypoxia ( J:306534 )

• primary hepatoma cells from myr-AKT and NRasV12 hypdrodynamic transfected mice show slower growth in hypoxia compared with normoxia ex vivo and slower growth in hypoxia compared to controls

cellular

abnormal mitochondrial morphology ( J:306534 )

• mice show distorted and atypical mitochondria with vacuoles or abnormal cristae in the hepatocellular carcinoma cells following hypdrodynamic transfection via tail-vein injection of oncogenes myr-AKT and NRasV12; mitochondrial abnormalities are not seen in controls

liver/biliary system

liver/biliary system phenotype ( J:306534 )

N • mice show no differences in liver function from controls