homeostasis/metabolism
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• mice show a higher hepatocellular carcinoma incidence, heavier liver to body weight ratio and larger tumor diameter following induction with DEN/CCl4
• DEN/CCl4-induced mice show a reduction in CD8+ T cell numbers and an induction of tumor-associated macrophages in tumors
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• in a CCl4-induced liver injury model, mice show more severe inflammation, liver function injury, and liver fibrosis than wild-type mice
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neoplasm
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• mice show a higher hepatocellular carcinoma incidence, heavier liver to body weight ratio and larger tumor diameter following induction with DEN/CCl4
• DEN/CCl4-induced mice show a reduction in CD8+ T cell numbers and an induction of tumor-associated macrophages in tumors
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immune system
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• DEN/CCl4-induced mice show a reduction in CD8+ T cell numbers
• however, no changes in percentages of other immune cells, including regulatory T cells, CD4+ T cells, B cells, and natural killer cells are seen in DEN/CCl4-induced mice
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hematopoietic system
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• DEN/CCl4-induced mice show a reduction in CD8+ T cell numbers
• however, no changes in percentages of other immune cells, including regulatory T cells, CD4+ T cells, B cells, and natural killer cells are seen in DEN/CCl4-induced mice
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