All Phenotypes Dzip1<tm1Sasl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dzip1^tm1Sasl
targeted mutation 1, Susan Slaugenhaupt
MGI:6718491

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dzip1^tm1Sasl/Dzip1^tm1Sasl Nfatc1^tm1.1(cre)Bz/Nfatc1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:6718507

Allelic Composition	Dzip1^tm1Sasl/Dzip1^tm1Sasl Nfatc1^tm1.1(cre)Bz/Nfatc1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dzip1^tm1Sasl mutation (0 available); any Dzip1 mutation (38 available)
Nfatc1^tm1.1(cre)Bz mutation (0 available); any Nfatc1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal mitral valve morphology ( J:291454 )

• reduced cilia length in valve mesenchyme

• adult mice exhibit myxomatous mitral valves with loss of normal extracellular matrix distribution

abnormal mitral valve cusp morphology ( J:291454 )

• elongated leaflet

mitral valve prolapse ( J:291454 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
mitral valve prolapse		DOID:988	OMIM:157700 OMIM:607829 OMIM:610840	J:291454

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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