All Phenotypes Hbs1l<tm1c(KOMP)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hbs1l^{tm1c(KOMP)Wtsi}
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:6718578

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hbs1l^{tm1c(KOMP)Wtsi}/Hbs1l^{tm1c(KOMP)Wtsi} En1^tm2(cre)Wrst/En1⁺	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6NTac	MGI:6718853
cn2	Hbs1l^{tm1c(KOMP)Wtsi}/Hbs1l^{tm1c(KOMP)Wtsi} Tg(Atoh1-cre)1Bfri/0	involves: 129S4/SvJaeSor * C57BL/6NTac * CBA	MGI:6718859
cn3	Hbs1l^{tm1c(KOMP)Wtsi}/Hbs1l^{tm1c(KOMP)Wtsi} Tg(Gabra6-cre)B1Lfr/0	involves: 129S4/SvJaeSor * C57BL/6NTac * DBA/2	MGI:6718856

Allelic Composition	Hbs1l^{tm1c(KOMP)Wtsi}/Hbs1l^{tm1c(KOMP)Wtsi} En1^tm2(cre)Wrst/En1⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm2(cre)Wrst mutation (1 available); any En1 mutation (34 available)
Hbs1l^{tm1c(KOMP)Wtsi} mutation (0 available); any Hbs1l mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased neuronal precursor proliferation ( J:306384 )

• more GABAergic precursors are retained between E12.5 and E16.5 due to increased proliferation

abnormal cerebellum morphology ( J:306384 )

• cerebellar defects are not rescued by restoration or complete deletion of n-TRtct5

abnormal cerebellar foliation ( J:306384 )

• delayed at P0 with failure of secondary fissures to form

• however, the trilaminar structure is normal at P21

decreased Purkinje cell number ( J:306384 )

• reduced ventricular zone-derived Lhx1/5+ Purkinje cells between E12.5 and E16.5

small cerebellum ( J:306384 )

• by E13.5

abnormal GABAergic neuron morphology ( J:306384 )

• more GABAergic precursors are retained between E12.5 and E16.5 due to increased proliferation

decreased neuronal precursor cell number ( J:306384 )

• reduced Pax2+ interneuron precursors between E12.5 and E16.5

• reduced granule cell precursors at E13.5 to E16.5

• reduced oligodendroglial progenitors at P5

• however, granule cell precursor proliferation is normal at E16.5 and P5

cellular

increased neuronal precursor proliferation ( J:306384 )

• more GABAergic precursors are retained between E12.5 and E16.5 due to increased proliferation

Allelic Composition	Hbs1l^{tm1c(KOMP)Wtsi}/Hbs1l^{tm1c(KOMP)Wtsi} Tg(Atoh1-cre)1Bfri/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6NTac * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbs1l^{tm1c(KOMP)Wtsi} mutation (0 available); any Hbs1l mutation (51 available)
Tg(Atoh1-cre)1Bfri mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:306384 )

N	• mice exhibit normal granule cell precursors

Allelic Composition	Hbs1l^{tm1c(KOMP)Wtsi}/Hbs1l^{tm1c(KOMP)Wtsi} Tg(Gabra6-cre)B1Lfr/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6NTac * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbs1l^{tm1c(KOMP)Wtsi} mutation (0 available); any Hbs1l mutation (51 available)
Tg(Gabra6-cre)B1Lfr mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:306384 )

N	• mice exhibit normal cell survival of terminally differentiated granule cells even in the presence of the n-TRtct5 deficiency

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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