Phenotypes associated with this allele

• Allele Symbol: Pelo^tm1Slac
• Allele Name: targeted mutation 1, Susan L Ackerman
• Allele ID: MGI:6718611
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pelo^tm1Slac/Pelo^tm1Slac En1^tm2(cre)Wrst/En1^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:6718863
cn2	Pelo^tm1Slac/Pelo^tm1Slac Tg(Atoh1-cre)1Bfri/0	involves: C57BL/6J * CBA	MGI:6718864
cn3	Pelo^tm1Slac/Pelo^tm1Slac Tg(Gabra6-cre)B1Lfr/0	involves: C57BL/6J * DBA/2	MGI:6718862

Genotype
MGI:6718863

cn1

• Allelic Composition: Pelo^tm1Slac/Pelo^tm1Slac; En1^tm2(cre)Wrst/En1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased neuron apoptosis ( J:306384 )

• increased apoptotic cells in the cerebellum in both the ventricular zone and the prospective white matter

increased neuronal precursor proliferation ( J:306384 )

• in the ventricular zone progenitors at E13.5

abnormal cerebellum external granule cell layer morphology ( J:306384 )

• missing at E13.5 and P0

abnormal brain interneuron morphology ( J:306384 )

• decreased Pax2+ interneurons

decreased inferior colliculus size ( J:306384 )

• grossly hypoplastic being nearly absent

decreased superior colliculus size ( J:306384 )

• grossly hypoplastic being nearly absent

decreased Purkinje cell number ( J:306384 )

• reduced Lhx1/5+ Purkinje cells

cerebellum hypoplasia ( J:306384 )

• grossly being nearly absent

loss of GABAergic neurons ( J:306384 )

• at E13.5 in the cerebellum

cellular

increased neuron apoptosis ( J:306384 )

• increased apoptotic cells in the cerebellum in both the ventricular zone and the prospective white matter

increased neuronal precursor proliferation ( J:306384 )

• in the ventricular zone progenitors at E13.5

Genotype
MGI:6718864

cn2

• Allelic Composition: Pelo^tm1Slac/Pelo^tm1Slac; Tg(Atoh1-cre)1Bfri/0
• Genetic Background: involves: C57BL/6J * CBA

nervous system

increased neuronal precursor proliferation ( J:306384 )

• reduced fraction of granule cell precursors exiting the cell cycle in the anterior lobes of the cerebellum

abnormal cerebellum external granule cell layer morphology ( J:306384 )

• no clear separation of the inner and outer external granule cell layer

decreased cerebellar granule cell number ( J:306384 )

• at P6 in the inner granule layer

abnormal cerebellum anterior lobe morphology ( J:306384 )

• reduced length with failure of Purkinje cells to form a monolayer

• however, the posterior lobes are normal

cellular

increased neuronal precursor proliferation ( J:306384 )

• reduced fraction of granule cell precursors exiting the cell cycle in the anterior lobes of the cerebellum

Genotype
MGI:6718862

cn3

• Allelic Composition: Pelo^tm1Slac/Pelo^tm1Slac; Tg(Gabra6-cre)B1Lfr/0
• Genetic Background: involves: C57BL/6J * DBA/2

nervous system

nervous system phenotype ( J:306384 )

N • mice exhibit normal cell survival of terminally differentiated granule cells even in the presence of the n-TRtct5 deficiency