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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rab26em1Guwa
endonuclease-mediated mutation 1, Guansong Wang
MGI:6719236
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rab26em1Guwa/Rab26em1Guwa Not Specified MGI:6719237


Genotype
MGI:6719237
hm1
Allelic
Composition
Rab26em1Guwa/Rab26em1Guwa
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rab26em1Guwa mutation (0 available); any Rab26 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice exhibit higher mortality than wild-type controls in response to a sublethal dose of LPS
• mice show aggravated LPS-induced acute lung injury, showing more congestion, alveolar collapse, thickening of the alveolar walls, a dramatic increase in bronchoalveolar lavage fluid protein content, lung edema, and pulmonary microvascular permeability in the lungs compared to wild-type controls

immune system
• mice show aggravated LPS-induced acute lung injury, showing more congestion, alveolar collapse, thickening of the alveolar walls, a dramatic increase in bronchoalveolar lavage fluid protein content, lung edema, and pulmonary microvascular permeability in the lungs compared to wild-type controls
• mice exhibit higher mortality than wild-type controls in response to a sublethal dose of LPS
• however, mice do not show changes in the lungs under physiological conditions

mortality/aging
• mice exhibit higher mortality than wild-type controls in response to a sublethal dose of LPS





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory