homeostasis/metabolism
• mice exhibit higher mortality than wild-type controls in response to a sublethal dose of LPS
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• mice show aggravated LPS-induced acute lung injury, showing more congestion, alveolar collapse, thickening of the alveolar walls, a dramatic increase in bronchoalveolar lavage fluid protein content, lung edema, and pulmonary microvascular permeability in the lungs compared to wild-type controls
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immune system
• mice show aggravated LPS-induced acute lung injury, showing more congestion, alveolar collapse, thickening of the alveolar walls, a dramatic increase in bronchoalveolar lavage fluid protein content, lung edema, and pulmonary microvascular permeability in the lungs compared to wild-type controls
• mice exhibit higher mortality than wild-type controls in response to a sublethal dose of LPS
• however, mice do not show changes in the lungs under physiological conditions
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mortality/aging
• mice exhibit higher mortality than wild-type controls in response to a sublethal dose of LPS
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