Phenotypes associated with this allele

• Allele Symbol: Gucy1b2^{tm4.1(cre)Mom}
• Allele Name: targeted mutation 4.1, Peter Mombaerts
• Allele ID: MGI:6719255
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cnga2^tm1.1Kob/Cnga2^tm1.1Kob Gucy1b2^tm4.1(cre)Mom/Gucy1b2^tm4.1(cre)Mom	involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J	MGI:6725113
cn2	Cnga2^tm1.1Kob/Y Gucy1b2^tm4.1(cre)Mom/Gucy1b2^tm4.1(cre)Mom	involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J	MGI:6725731

Genotype
MGI:6725113

cn1

• Allelic Composition: Cnga2^tm1.1Kob/Cnga2^tm1.1Kob; Gucy1b2^{tm4.1(cre)Mom}/Gucy1b2^{tm4.1(cre)Mom}
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal response to novel odor ( J:307157 )

• with CNGA2 absent from type B olfactory sensory neurons, homozygotes fail to respond to NaHS by the usual dose-dependent avoidance behavior or the increased stress-induced self-grooming that occurs in controls, but they do respond with normal avoidance to hypoxia. They also fail to increase serum adrenocorticotropic hormone levels in response to NaHS, but do respond to the non-olfactory stressor of a forced swim test with increased serum adrenocorticotropic hormone levels, confirming the non-response to NaHS.

homeostasis/metabolism

abnormal homeostasis ( J:307157 )

• Type B olfactory sensory neurons of the main olfactory epithelium respond normally to hypoxia but fail to respond to NaHS

Genotype
MGI:6725731

cn2

• Allelic Composition: Cnga2^tm1.1Kob/Y; Gucy1b2^{tm4.1(cre)Mom}/Gucy1b2^{tm4.1(cre)Mom}
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J

behavior/neurological

abnormal response to novel odor ( J:307157 )

• with CNGA2 absent from type B olfactory sensory neurons, homozygotes fail to respond to NaHS by the usual dose-dependent avoidance behavior that occurs in controls

homeostasis/metabolism

abnormal homeostasis ( J:307157 )

• Type B olfactory sensory neurons of the main olfactory epithelium respond normally to hypoxia but fail to respond to NaHS