Phenotypes associated with this allele

• Allele Symbol: Nup160^tm1Mdan
• Allele Name: targeted mutation 1, Maximiliano A D'Angelo
• Allele ID: MGI:6719493
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nup160^tm1Mdan/Nup160^tm1Mdan Gt(ROSA)26Sor^tm1(cre/ERT2)Tyj/Gt(ROSA)26Sor^+	involves: 129S4/SvJae * C57BL/6	MGI:6719494

Genotype
MGI:6719494

cn1

• Allelic Composition: Nup160^tm1Mdan/Nup160^tm1Mdan; Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal hematopoietic stem cell physiology ( J:301567 )

• hematopoietic progenitors at 72 hours of tamoxifen treatment show a decrease in the number of EdU+ positive cells and an increase in the G1 population, indicating an arrest in G1

decreased hematopoietic stem cell proliferation ( J:301567 )

• primary hematopoietic progenitors in culture treated with tamoxifen show a decrease in cell numbers over time, however an increase in cell death is not seen, indicating a cell cycle arrest

cellular

decreased hematopoietic stem cell proliferation ( J:301567 )

• primary hematopoietic progenitors in culture treated with tamoxifen show a decrease in cell numbers over time, however an increase in cell death is not seen, indicating a cell cycle arrest