Phenotypes associated with this allele

• Allele Symbol: Tspan9^em1Tshu
• Allele Name: endonuclease-mediated mutation 1, Tsinghua University
• Allele ID: MGI:6719497
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tspan9^em1Tshu/Tspan9^em1Tshu	C57BL/6-Tspan9^em1Tshu	MGI:6719500

Genotype
MGI:6719500

hm1

• Allelic Composition: Tspan9^em1Tshu/Tspan9^em1Tshu
• Genetic Background: C57BL/6-Tspan9^em1Tshu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal neutrophil morphology ( J:307067 )

• reduced mitocytosis-associated migrasome formation in neutrophils with loss of mitochondrial membrane potential (MPP)

decreased neutrophil cell number ( J:307067 )

• in the spleen due to reduced viability associated with impaired mitocytosis

abnormal macrophage morphology ( J:307067 )

• reduced mitocytosis-associated migrasome formation in bone marrow-derived macrophages

• loss of mitochondrial membrane potential (MPP) in bone marrow-derived and peritoneal macrophages

• however, MPP in immobile hepatocytes is normal

immune system

abnormal neutrophil morphology ( J:307067 )

• reduced mitocytosis-associated migrasome formation in neutrophils with loss of mitochondrial membrane potential (MPP)

decreased neutrophil cell number ( J:307067 )

• in the spleen due to reduced viability associated with impaired mitocytosis

abnormal macrophage morphology ( J:307067 )

• reduced mitocytosis-associated migrasome formation in bone marrow-derived macrophages

• loss of mitochondrial membrane potential (MPP) in bone marrow-derived and peritoneal macrophages

• however, MPP in immobile hepatocytes is normal