About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Shld1em1Nus
endonuclease-mediated mutation 1, Andre Nussenzweig
MGI:6719506
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Shld1em1Nus/Shld1em1Nus involves: C57BL/6NCrl MGI:6739935
cx2
 		Brca1tm2.1Cxd/Brca1tm2.1Cxd
Shld1em1Nus/Shld1em1Nus 		involves: 129S6/SvEvTac * C57BL/6NCrl MGI:6739936


Genotype
MGI:6739935
hm1
Allelic
Composition		 Shld1em1Nus/Shld1em1Nus
Genetic
Background		 involves: C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shld1em1Nus mutation (0 available); any Shld1 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:307190 )
• mice show defects in IgG1 class switch recombination

hematopoietic system
abnormal class switch recombination ( J:307190 )
• mice show defects in IgG1 class switch recombination

mortality/aging
mortality/aging ( J:307190 )
N
• mice are viable and do not show any overt phenotypes




Genotype
MGI:6739936
cx2
Allelic
Composition		 Brca1tm2.1Cxd/Brca1tm2.1Cxd
Shld1em1Nus/Shld1em1Nus
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2.1Cxd mutation (1 available); any Brca1 mutation (114 available)
Shld1em1Nus mutation (0 available); any Shld1 mutation (78 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:307190 )
• mice show defects in IgG1 class switch recombination

hematopoietic system
abnormal class switch recombination ( J:307190 )
• mice show defects in IgG1 class switch recombination

cellular
chromosomal instability ( J:307190 )
• PARPi-induced genome instability is lower in primary B cells compared to that seen in homozygous Brca1 mutant cells but still increased compared to in wild-type cells

mortality/aging
mortality/aging ( J:307190 )
N
• the expected Mendelian ratio of mice are obtained, indicating rescue of the embryonic lethality of homozygous Brca1 mutants




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory