About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Agap3tm1Ygi
targeted mutation 1, Shigeru Yanagi
MGI:6719542
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Agap3tm1Ygi/Agap3tm1Ygi
Tg(Emx1-cre)#Ito/0 		involves: C57BL/6 MGI:6719550
cn2
 		Agap3tm1Ygi/Agap3tm1Ygi
Tg(Nes-cre)1Kln/0 		involves: C57BL/6 * SJL MGI:6719551


Genotype
MGI:6719550
cn1
Allelic
Composition		 Agap3tm1Ygi/Agap3tm1Ygi
Tg(Emx1-cre)#Ito/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agap3tm1Ygi mutation (0 available); any Agap3 mutation (38 available)
Tg(Emx1-cre)#Ito mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal dentate gyrus morphology ( J:306994 )
• immature dentate gyrus with decreased mature neuron numbers
decreased neuron number ( J:306994 )
• decreased mature neurons in the dentate gyrus

behavior/neurological
hyperactivity ( J:306994 )
• at P21 and 8 weeks without increased anxiety




Genotype
MGI:6719551
cn2
Allelic
Composition		 Agap3tm1Ygi/Agap3tm1Ygi
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agap3tm1Ygi mutation (0 available); any Agap3 mutation (38 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:306994 )
• survival is similar to in Agap3tm1.1Ygi homozygotes

growth/size/body
decreased body size ( J:306994 )
decreased body weight ( J:306994 )

behavior/neurological
hyperactivity ( J:306994 )
• hyperactivity and increased distance traveled in an open-field test
increased locomotor activity ( J:306994 )
• in an open field test




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory