Phenotypes associated with this allele

• Allele Symbol: Parp9^tm1.2Arte
• Allele Name: targeted mutation 1.2, TaconicArtemis
• Allele ID: MGI:6721053
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Parp9^tm1.2Arte/Parp9^tm1.2Arte	involves: C57BL/6N * FVB/N	MGI:6724578

Genotype
MGI:6724578

hm1

• Allelic Composition: Parp9^tm1.2Arte/Parp9^tm1.2Arte
• Genetic Background: involves: C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal circulating interferon level ( J:306337 )

• reduced type I IFN in the sera of mice infected with VSV

abnormal interferon secretion ( J:306337 )

• less type I IFN from bone marrow dendritic cells infected with RNA viruses

• however, response to polyI:C is normal

abnormal response to infection ( J:306337 )

• bone marrow dendritic cells infected with RNA viruses produce less type I IFN compared with wild-type cells

• mice infected with VSV exhibit higher viral titers in the liver, lungs, spleen, and brains, and reduced type I IFN in the sera compared with wild-type mice

• however, response to polyI:C is normal as are the levels of inflammatory cytokines following VSV infection

homeostasis/metabolism

abnormal circulating interferon level ( J:306337 )

• reduced type I IFN in the sera of mice infected with VSV