All Phenotypes Cox4i2<tm1.1Jlob> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cox4i2^tm1.1Jlob
targeted mutation 1.1, Jose Lopez-Barneo
MGI:6721093

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cox4i2^tm1Hutt/Cox4i2^tm1.1Jlob Th^tm1(cre)Te/Th⁺	involves: 129X1/SvJ * C57BL/6	MGI:6724164

Allelic Composition	Cox4i2^tm1Hutt/Cox4i2^tm1.1Jlob Th^tm1(cre)Te/Th⁺
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cox4i2^tm1.1Jlob mutation (0 available); any Cox4i2 mutation (13 available)
Cox4i2^tm1Hutt mutation (0 available); any Cox4i2 mutation (13 available)
Th^tm1(cre)Te mutation (1 available); any Th mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal physiological response to hypoxia ( J:302384 )

• loss of acute responsiveness to hypoxia with decreased glomus cells exhibiting increased cytosolic calcium ions and catecholamine release, and decreased mitochondrial responses to hypoxia

• however, mitochondria complex IV function is normal and ventilatory response to hypercapnia is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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