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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(AMH-Gja1*)#Sinos
transgene insertion, Satoshi Inoue
MGI:6721407
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ggcxtm1Sinos/Ggcxtm1Sinos
Tg(AMH-cre)#Sinos/0
Tg(AMH-Gja1*)#Sinos/0 		involves: 129S2/SvPas * C57BL/6 MGI:6842960


Genotype
MGI:6842960
cn1
Allelic
Composition		 Ggcxtm1Sinos/Ggcxtm1Sinos
Tg(AMH-cre)#Sinos/0
Tg(AMH-Gja1*)#Sinos/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ggcxtm1Sinos mutation (1 available); any Ggcx mutation (37 available)
Tg(AMH-cre)#Sinos mutation (0 available)
Tg(AMH-Gja1*)#Sinos mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:307381 )
N
• mice exhibit normal male fertility at 2 and 8 months of age and show no significant alterations in testis size, testis weight and seminiferous tubule histology or in GJA1 (Cx43) protein distribution at 8 months of age relative to controls, indicating that GJA1 overexpression in Sertoli cells rescues the sterility and testicular pathology phenotypes observed in Sertoli cell-specific Ggcx conditional knockout mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory