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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dcaf8em1Rbren
endonuclease-mediated mutation 1, Ruibao Ren
MGI:6724058
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dcaf8em1Rbren/Dcaf8em1Rbren Not Specified MGI:6724059


Genotype
MGI:6724059
hm1
Allelic
Composition		 Dcaf8em1Rbren/Dcaf8em1Rbren
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcaf8em1Rbren mutation (0 available); any Dcaf8 mutation (125 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased copulatory plug deposition ( J:307635 )
• reduced frequency of copulation plugs compared to wild type control

cellular
abnormal sperm head morphology ( J:307635 )
• more than 40% of spermatids show bent head malformations
decreased sperm progressive motility ( J:307635 )
• progressive motility, path velocity (VAP), progressive velocity (VSL), and track speed (VCL) were significantly lower

reproductive system
abnormal sperm head morphology ( J:307635 )
• more than 40% of spermatids show bent head malformations
decreased sperm progressive motility ( J:307635 )
• progressive motility, path velocity (VAP), progressive velocity (VSL), and track speed (VCL) were significantly lower
reduced male fertility ( J:307635 )
• in addition to reduced male fertility by mating, the homozygous male showed the severely reduced in vitro fertilization rates




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory