Phenotypes associated with this allele

• Allele Symbol: Cd302^tm1.1Dnjh
• Allele Name: targeted mutation 1.1, Derek NJ Hart
• Allele ID: MGI:6724312
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd302^tm1.1Dnjh/Cd302^tm1.1Dnjh	involves: C57BL/6	MGI:6724322

Genotype
MGI:6724322

hm1

• Allelic Composition: Cd302^tm1.1Dnjh/Cd302^tm1.1Dnjh
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:301848 )

N • mice exhibit normal dendritic cells chemotaxis toward CCL19/21 and in vivo macrophage migration into the peritoneal cavity

decreased dendritic cell number ( J:301848 )

• reduced migratory lymph node dendritic cells

• however, numbers are normal in the bone marrow, spleen and thymus

abnormal CD8-positive, alpha-beta T cell physiology ( J:301848 )

• reduced antigen-specific CD8+ T cell response initiated by deficient antibody presenting cells

abnormal dendritic cell physiology ( J:301848 )

• reduced in vivo migration from peripheral sites into draining lymph nodes and decreased entry into the interfollicular channels

hematopoietic system

decreased dendritic cell number ( J:301848 )

• reduced migratory lymph node dendritic cells

• however, numbers are normal in the bone marrow, spleen and thymus

abnormal CD8-positive, alpha-beta T cell physiology ( J:301848 )

• reduced antigen-specific CD8+ T cell response initiated by deficient antibody presenting cells