Phenotypes associated with this allele

• Allele Symbol: Prrc2a^tm1Fcw
• Allele Name: targeted mutation 1, Fengchao Wang
• Allele ID: MGI:6724325
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Prrc2a^tm1Fcw/Prrc2a^tm1Fcw Olig2^tm2(TVA,cre)Rth/Olig2^+	involves: 129 * C57BL/6	MGI:6724442
cn2	Prrc2a^tm1Fcw/Prrc2a^tm1Fcw Tg(Gfap-cre)77.6Mvs/0	involves: BALB/c * C57BL/6NHsd	MGI:6724443
cn3	Prrc2a^tm1Fcw/Prrc2a^tm1Fcw Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:6724441

Genotype
MGI:6724442

cn1

• Allelic Composition: Prrc2a^tm1Fcw/Prrc2a^tm1Fcw; Olig2^{tm2(TVA,cre)Rth}/Olig2⁺
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:301796 )

nervous system

nervous system phenotype ( J:301796 )

N • mice exhibit normal ventral neuron numbers in the spinal cord

abnormal brain morphology ( J:301796 )

• however, neuron number is normal

decreased oligodendrocyte progenitor number ( J:301796 )

increased brain weight ( J:301796 )

enlarged lateral ventricles ( J:301796 )

abnormal corpus callosum morphology ( J:301796 )

• increased signal density on MRIs

• hypomyelination in the corpus callosum at 4 weeks of age and in adults

decreased oligodendrocyte number ( J:301796 )

dysmyelination ( J:301796 )

growth/size/body

decreased body weight ( J:301796 )

behavior/neurological

impaired spatial learning ( J:301796 )

impaired coordination ( J:301796 )

decreased grip strength ( J:301796 )

cellular

decreased oligodendrocyte progenitor number ( J:301796 )

Genotype
MGI:6724443

cn2

• Allelic Composition: Prrc2a^tm1Fcw/Prrc2a^tm1Fcw; Tg(Gfap-cre)77.6Mvs/0
• Genetic Background: involves: BALB/c * C57BL/6NHsd

nervous system

nervous system phenotype ( J:301796 )

N • mice exhibit normal myelination and oligodendrocyte and astrocyte populations

Genotype
MGI:6724441

cn3

• Allelic Composition: Prrc2a^tm1Fcw/Prrc2a^tm1Fcw; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: C57BL/6 * SJL

mortality/aging

premature death ( J:301796 )

nervous system

abnormal brain morphology ( J:301796 )

• however, neuron number is normal

abnormal brain development ( J:301796 )

• impaired oligodendrocyte progenitor cell generation and proliferation with increased oligodendrocyte differentiation

decreased oligodendrocyte progenitor number ( J:301796 )

increased brain weight ( J:301796 )

enlarged lateral ventricles ( J:301796 )

abnormal corpus callosum morphology ( J:301796 )

• increased signal density on MRIs

• hypomyelination in the corpus callosum at 4 weeks of age and in adults

decreased astrocyte number ( J:301796 )

• slight

decreased oligodendrocyte number ( J:301796 )

abnormal astrocyte physiology ( J:301796 )

• reduced proliferation

dysmyelination ( J:301796 )

• in the corpus callosum at 4 weeks of age and in adults

• reduced myelinated axons and myelin thickness in different brain regions

decreased nerve conduction velocity ( J:301796 )

• impaired callosal conduction velocity

growth/size/body

decreased body weight ( J:301796 )

behavior/neurological

impaired spatial learning ( J:301796 )

• learning and memory defects

impaired coordination ( J:301796 )

• on a rotarod

decreased grip strength ( J:301796 )

cellular

decreased oligodendrocyte progenitor number ( J:301796 )