Phenotypes associated with this allele

• Allele Symbol: Tfpi2^tm1Dgen
• Allele Name: targeted mutation 1, Deltagen
• Allele ID: MGI:6724439
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tfpi2^tm1Dgen/Tfpi2^tm1Dgen	involves: 129P2/OlaHsd * C57BL/6J	MGI:6724440

Genotype
MGI:6724440

hm1

• Allelic Composition: Tfpi2^tm1Dgen/Tfpi2^tm1Dgen
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:301794 )

• in mice infected intranasally with P. aeruginosa

immune system

immune system phenotype ( J:301794 )

N • LPS-challenged mice exhibit normal clotting time, platelet counts, and cytokine serum levels

increased circulating interleukin-10 level ( J:301794 )

• in mice infected intranasally with P. aeruginosa

increased circulating interleukin-6 level ( J:301794 )

• in mice infected intranasally with P. aeruginosa

increased interleukin-10 secretion ( J:301794 )

• in mice infected intranasally with P. aeruginosa

increased susceptibility to bacterial infection ( J:301794 )

• mice infected intranasally with P. aeruginosa exhibit lower survival, increased viral load (in the bronchioalveolar fluid and lung tissue), higher plasma levels of IL6, IL10, and CCL2, and higher bronchioalveolar fluid levels of IL10 and CCL2 compared with wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:301794 )

• in mice infected intranasally with P. aeruginosa

homeostasis/metabolism

increased circulating interleukin-10 level ( J:301794 )

• in mice infected intranasally with P. aeruginosa

increased circulating interleukin-6 level ( J:301794 )

• in mice infected intranasally with P. aeruginosa