Phenotypes associated with this allele

• Allele Symbol: Pramel13^em2Dean
• Allele Name: endonuclease-mediated mutation 2, Jurrien Dean
• Allele ID: MGI:6724473
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pramel13^em2Dean/Pramel13^em2Dean	involves: C57BL/6J * DBA/2J	MGI:6724557

Genotype
MGI:6724557

hm1

• Allelic Composition: Pramel13^em2Dean/Pramel13^em2Dean
• Genetic Background: involves: C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:282232 )

♀ • female mice exhibit normal fertility

azoospermia ( J:282232 )

♂ • depleted or significantly reduced spermatogonia at P7

♂ • no sperm are present in the cauda epididymide

increased male germ cell apoptosis ( J:282232 )

♂

abnormal spermatogonia proliferation ( J:282232 )

♂ • defective proliferative expansion of spermatogonia

small testis ( J:282232 )

♂ • however, transgene expression of the endogenous gene rescues phenotype

decreased testis weight ( J:282232 )

♂ • beginning at P14

♂ • however, transgene expression of the endogenous gene rescues phenotype

male infertility ( J:282232 )

♂ • however, transgene expression of the endogenous gene rescues phenotype

cellular

azoospermia ( J:282232 )

♂ • depleted or significantly reduced spermatogonia at P7

♂ • no sperm are present in the cauda epididymide

increased male germ cell apoptosis ( J:282232 )

♂

abnormal spermatogonia proliferation ( J:282232 )

♂ • defective proliferative expansion of spermatogonia

endocrine/exocrine glands

small testis ( J:282232 )

♂ • however, transgene expression of the endogenous gene rescues phenotype

decreased testis weight ( J:282232 )

♂ • beginning at P14

♂ • however, transgene expression of the endogenous gene rescues phenotype