About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tulp2em1Huizh
endonuclease-mediated mutation 1, Hui Zhu
MGI:6724546
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tulp2em1Huizh/Tulp2em1Huizh C57BL/6-Tulp2em1Huizh MGI:6724569


Genotype
MGI:6724569
hm1
Allelic
Composition		 Tulp2em1Huizh/Tulp2em1Huizh
Genetic
Background		 C57BL/6-Tulp2em1Huizh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tulp2em1Huizh mutation (0 available); any Tulp2 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:307539 )
N
• fertile and normal litter size
abnormal sperm axoneme morphology ( J:307539 )
• incomplete or disorganized 2+9 microtubule arrangement
abnormal sperm midpiece morphology ( J:307539 )
• incomplete peripheral dense fibers
kinked sperm flagellum ( J:307539 )
• in cauda, caput and corpus epididymis
oligozoospermia ( J:307539 )
• low sperm count in cauda epididymis and lumen of epididymis duct
abnormal spermatid morphology ( J:307539 )
• retained elongated spermatids in middle and base of stage VII-X seminiferous tubules
increased testis apoptosis ( J:307539 )
• significant increase in average number of apoptotic cells per tubule
• significant increase in elongated spermatid apoptosis
decreased sperm progressive motility ( J:307539 )
• low progressive motility of sperm from cauda epididymis
asthenozoospermia ( J:307539 )
• low motility of sperm from cauda epididymis

endocrine/exocrine glands
increased testis apoptosis ( J:307539 )
• significant increase in average number of apoptotic cells per tubule
• significant increase in elongated spermatid apoptosis

cellular
abnormal sperm axoneme morphology ( J:307539 )
• incomplete or disorganized 2+9 microtubule arrangement
abnormal sperm midpiece morphology ( J:307539 )
• incomplete peripheral dense fibers
kinked sperm flagellum ( J:307539 )
• in cauda, caput and corpus epididymis
oligozoospermia ( J:307539 )
• low sperm count in cauda epididymis and lumen of epididymis duct
abnormal spermatid morphology ( J:307539 )
• retained elongated spermatids in middle and base of stage VII-X seminiferous tubules
abnormal mitochondrial crista morphology ( J:307539 )
• absent inner mitochondrial membrane cristae in sperm flagella
increased testis apoptosis ( J:307539 )
• significant increase in average number of apoptotic cells per tubule
• significant increase in elongated spermatid apoptosis
decreased sperm progressive motility ( J:307539 )
• low progressive motility of sperm from cauda epididymis
asthenozoospermia ( J:307539 )
• low motility of sperm from cauda epididymis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory