Analysis Tools
immune system
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• females intravaginally infected with Chlamydia muridarum exhibit lower CXCL1 secretion at 1 week, higher in week 2, and lower in week 4 of infection compared to wild-type mice
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• females intravaginally infected with Chlamydia muridarum exhibit lower IFN-gamma secretion in the vaginal lavage
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• females intravaginally infected with Chlamydia muridarum exhibit lower IL-12 secretion in the vaginal lavage
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• females intravaginally infected with Chlamydia muridarum exhibit lower TNF-alpha secretion in the vaginal lavage
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• females intravaginally infected with Chlamydia muridarum exhibit higher bacterial load from day 18 to 27 post-infection and are unable to clear the infection, however mice show reduced uterine dilatations and pathologic lesions than infected wild-type mice indicating a protective effect against developing genital tract pathology
• females intravaginally infected with Chlamydia muridarum exhibit lower TNF-alpha, IFN-gamma, and IL-12 secretion in the vaginal lavage, indicating a dampening of pro-inflammatory immune response following infection
• pregnancy and fertility rates of infected mutant females show protection from Chlamydia-induced infertility with 100% fertility compared to 50% in infected wild-type mice
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reproductive system
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• pregnancy and fertility rates of infected mutant females show protection from Chlamydia-induced infertility with 100% fertility compared to 50% in infected wild-type mice
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