All Phenotypes Cnga2<tm1.1Kob> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cnga2^tm1.1Kob
targeted mutation 1.1, Reiko Kobayakawa
MGI:6725108

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cnga2^tm1.1Kob/Cnga2^tm1.1Kob Gucy1b2^{tm4.1(cre)Mom}/Gucy1b2^{tm4.1(cre)Mom}	involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J	MGI:6725113
cn2	Cnga2^tm1.1Kob/Y Gucy1b2^{tm4.1(cre)Mom}/Gucy1b2^{tm4.1(cre)Mom}	involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J	MGI:6725731

Allelic Composition	Cnga2^tm1.1Kob/Cnga2^tm1.1Kob Gucy1b2^{tm4.1(cre)Mom}/Gucy1b2^{tm4.1(cre)Mom}
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2^tm1.1Kob mutation (0 available); any Cnga2 mutation (17 available)
Gucy1b2^{tm4.1(cre)Mom} mutation (1 available); any Gucy1b2 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal response to novel odor ( J:307157 )

• with CNGA2 absent from type B olfactory sensory neurons, homozygotes fail to respond to NaHS by the usual dose-dependent avoidance behavior or the increased stress-induced self-grooming that occurs in controls, but they do respond with normal avoidance to hypoxia. They also fail to increase serum adrenocorticotropic hormone levels in response to NaHS, but do respond to the non-olfactory stressor of a forced swim test with increased serum adrenocorticotropic hormone levels, confirming the non-response to NaHS.

homeostasis/metabolism

abnormal homeostasis ( J:307157 )

• Type B olfactory sensory neurons of the main olfactory epithelium respond normally to hypoxia but fail to respond to NaHS

Allelic Composition	Cnga2^tm1.1Kob/Y Gucy1b2^{tm4.1(cre)Mom}/Gucy1b2^{tm4.1(cre)Mom}
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor * C57BL/6J