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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gas2tm1c(EUCOMM)Hmgu
targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
MGI:6725132
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gas2tm1c(EUCOMM)Hmgu/Gas2tm1c(EUCOMM)Hmgu
Sox2tm1(cre/ERT2)Hoch/Sox2+ 		involves: 129S4/SvJae * C57BL/6 * C57BL/6N MGI:7282238


Genotype
MGI:7282238
cn1
Allelic
Composition		 Gas2tm1c(EUCOMM)Hmgu/Gas2tm1c(EUCOMM)Hmgu
Sox2tm1(cre/ERT2)Hoch/Sox2+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gas2tm1c(EUCOMM)Hmgu mutation (0 available); any Gas2 mutation (18 available)
Sox2tm1(cre/ERT2)Hoch mutation (1 available); any Sox2 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal pillar cell morphology ( J:306028 )
• progressive loss of pillar cell microtubules with age in tamoxifen-treated mice
increased or absent threshold for auditory brainstem response ( J:306028 )
• tamoxifen-treated mice show elevated auditory brainstem responses (ABR) across all frequencies tested at 2 months of age
abnormal distortion product otoacoustic emission ( J:306028 )
• distortion product otoacoustic emissions (DPOAEs) are reduced in tamoxifen-treated mice
impaired hearing ( J:306028 )
• tamoxifen-treated mice show hearing loss




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory