Phenotypes associated with this allele

• Allele Symbol: Mir24-1^em1Smoc
• Allele Name: endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• Allele ID: MGI:6725791
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mir24-1^em1Smoc/Mir24-1^em1Smoc Mir24-2^em1Smoc/Mir24-2^em1Smoc Tg(KRT14-cre)1Amc/0	involves: C57BL/6J * CBA	MGI:6726110

Genotype
MGI:6726110

cn1

• Allelic Composition: Mir24-1^em1Smoc/Mir24-1^em1Smoc; Mir24-2^em1Smoc/Mir24-2^em1Smoc; Tg(KRT14-cre)1Amc/0
• Genetic Background: involves: C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

integument phenotype ( J:306624 )

N • skin appears normal

increased keratinocyte proliferation ( J:306624 )

• in the interfollicular epidermis at P4, but not P20

• in vitro proliferation of primary keratinocytes at lower levels of minoxidil

• however, ectopic expression restores normal sensitivity

abnormal hair growth ( J:306624 )

• quicker recovery following shaving likely due to premature hair germ activation

• increased hair growth in response to 4.5 mm and 5.5 mm diameter hairs being plucked or low levels of minoxidil

• however, treatment with Plk3 shRNA or GW843682X, a Plk3 suppressor, restores sensitivity to minoxidil

cellular

increased keratinocyte proliferation ( J:306624 )

• in the interfollicular epidermis at P4, but not P20

• in vitro proliferation of primary keratinocytes at lower levels of minoxidil

• however, ectopic expression restores normal sensitivity