Phenotypes associated with this allele

• Allele Symbol: Fgf9^tm1.2Zqch
• Allele Name: targeted mutation 1.2, Zhenqi Chen
• Allele ID: MGI:6726116
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf9^tm1.2Zqch/Fgf9^tm1.2Zqch	involves: 129S6/SvEvTac * C57BL/6J * FVB	MGI:7378711
ht2	Fgf9^tm1.2Zqch/Fgf9^+	involves: 129S6/SvEvTac * C57BL/6J * FVB	MGI:7378715

Genotype
MGI:7378711

hm1

• Allelic Composition: Fgf9^tm1.2Zqch/Fgf9^tm1.2Zqch
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:306390 )

• die shortly after birth

craniofacial

abnormal occipital bone morphology ( J:306390 )

• occipital deficiency

small mandible ( J:306390 )

• mandibular length and width are about 15% lower compared to controls

short mandible ( J:306390 )

abnormal premaxilla morphology ( J:306390 )

• abnormal circular tip

abnormal palatal mesenchymal cell proliferation ( J:306390 )

• decrease in cell proliferation in the mesenchyme from E12.5 to E13.5

abnormal secondary palate development ( J:306390 )

• from E12.5 to E13.5 palatal shelves are smaller but the mesenchymal cell density is higher

• decrease in cell proliferation in both the epithelium and mesenchyme from E12.5 to E13.5

• at E12.5, decrease in hyaluronic acid accumulation, especially in the anterior region, with a lingual-buccal gradient

decreased palatal shelf size ( J:306390 )

• at E12.5 to E13.5

decreased mouth size ( J:306390 )

• reduced oral volume

abnormal secondary palate morphology ( J:306390 )

• the cuticular layer of the oral epithelium of the unfused palate is thickened

abnormal palate bone morphology ( J:306390 )

• trabecular bone is thin and separated with premature palatal mineralization especially in the anterior region

cleft secondary palate ( J:306390 )

• complete penetrance of significant cleft of the secondary palate

delayed palatal shelf elevation ( J:306390 )

narrow palate ( J:306390 )

abnormal tongue position ( J:306390 )

• tongue height relative to head height is increased

increased tongue size ( J:306390 )

narrow head ( J:306390 )

• head width is about 15% lower compared to controls

skeleton

abnormal occipital bone morphology ( J:306390 )

• occipital deficiency

small mandible ( J:306390 )

• mandibular length and width are about 15% lower compared to controls

short mandible ( J:306390 )

abnormal premaxilla morphology ( J:306390 )

• abnormal circular tip

abnormal palate bone morphology ( J:306390 )

• trabecular bone is thin and separated with premature palatal mineralization especially in the anterior region

premature bone ossification ( J:306390 )

• premature parietal ossification

abnormal cartilage physiology ( J:306390 )

• decrease in the ratio of proliferating to apoptotic cells in the Meckel's cartilage at E13.5

digestive/alimentary system

abnormal palatal mesenchymal cell proliferation ( J:306390 )

• decrease in cell proliferation in the mesenchyme from E12.5 to E13.5

abnormal secondary palate development ( J:306390 )

• from E12.5 to E13.5 palatal shelves are smaller but the mesenchymal cell density is higher

• decrease in cell proliferation in both the epithelium and mesenchyme from E12.5 to E13.5

• at E12.5, decrease in hyaluronic acid accumulation, especially in the anterior region, with a lingual-buccal gradient

decreased palatal shelf size ( J:306390 )

• at E12.5 to E13.5

abnormal secondary palate morphology ( J:306390 )

• the cuticular layer of the oral epithelium of the unfused palate is thickened

abnormal palate bone morphology ( J:306390 )

• trabecular bone is thin and separated with premature palatal mineralization especially in the anterior region

cleft secondary palate ( J:306390 )

• complete penetrance of significant cleft of the secondary palate

delayed palatal shelf elevation ( J:306390 )

narrow palate ( J:306390 )

abnormal tongue position ( J:306390 )

• tongue height relative to head height is increased

increased tongue size ( J:306390 )

growth/size/body

abnormal palatal mesenchymal cell proliferation ( J:306390 )

• decrease in cell proliferation in the mesenchyme from E12.5 to E13.5

abnormal secondary palate development ( J:306390 )

• from E12.5 to E13.5 palatal shelves are smaller but the mesenchymal cell density is higher

• decrease in cell proliferation in both the epithelium and mesenchyme from E12.5 to E13.5

• at E12.5, decrease in hyaluronic acid accumulation, especially in the anterior region, with a lingual-buccal gradient

decreased palatal shelf size ( J:306390 )

• at E12.5 to E13.5

decreased mouth size ( J:306390 )

• reduced oral volume

abnormal secondary palate morphology ( J:306390 )

• the cuticular layer of the oral epithelium of the unfused palate is thickened

abnormal palate bone morphology ( J:306390 )

• trabecular bone is thin and separated with premature palatal mineralization especially in the anterior region

cleft secondary palate ( J:306390 )

• complete penetrance of significant cleft of the secondary palate

delayed palatal shelf elevation ( J:306390 )

narrow palate ( J:306390 )

abnormal tongue position ( J:306390 )

• tongue height relative to head height is increased

increased tongue size ( J:306390 )

narrow head ( J:306390 )

• head width is about 15% lower compared to controls

homeostasis/metabolism

decreased hyaluronic acid level ( J:306390 )

• at E12.5, decrease in hyaluronic acid accumulation in the palate shelves, especially in the anterior region, with a lingual-buccal gradient

Genotype
MGI:7378715

ht2

• Allelic Composition: Fgf9^tm1.2Zqch/Fgf9⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB

craniofacial

small mandible ( J:306390 )

• decrease in mandible height and width

abnormal secondary palate development ( J:306390 )

• decrease in hyaluronic acid accumulation at E13.5

• decrease in cell proliferation at E14.5

delayed palatal shelf elevation ( J:306390 )

• in some embryos at E14.5 palatal elevation and contact are delayed, in others elevation is normal but contact is not present, and in the remainder elevation and contact are normal

skeleton

small mandible ( J:306390 )

• decrease in mandible height and width

digestive/alimentary system

abnormal secondary palate development ( J:306390 )

• decrease in hyaluronic acid accumulation at E13.5

• decrease in cell proliferation at E14.5

delayed palatal shelf elevation ( J:306390 )

• in some embryos at E14.5 palatal elevation and contact are delayed, in others elevation is normal but contact is not present, and in the remainder elevation and contact are normal

growth/size/body

abnormal secondary palate development ( J:306390 )

• decrease in hyaluronic acid accumulation at E13.5

• decrease in cell proliferation at E14.5

delayed palatal shelf elevation ( J:306390 )

• in some embryos at E14.5 palatal elevation and contact are delayed, in others elevation is normal but contact is not present, and in the remainder elevation and contact are normal