Phenotypes associated with this allele

• Allele Symbol: Tsga8^em1Ohbo
• Allele Name: endonuclease-mediated mutation 1, Kazuyuki Ohbo
• Allele ID: MGI:6726553
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Tsga8^em1Ohbo/Y	C57BL/6-Tsga8^em1Ohbo	MGI:6727060

Genotype
MGI:6727060

ot1

• Allelic Composition: Tsga8^em1Ohbo/Y
• Genetic Background: C57BL/6-Tsga8^em1Ohbo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:307409 )

N • normal testis appearance in males

N • females are fertile

increased testis apoptosis ( J:307409 )

♂ • 7.2x increase in apoptosis in seminiferous tubules

decreased testis weight ( J:307409 )

♂ • testis plus epididymis weight 14.5% lower

abnormal spermatogenesis ( J:307409 )

♂ • virtual lack of sperm in rete testis, efferent ducts, caput, corpus and cauda epididymal lumen

♂ • accumulation of abnormal cells in cauda epididymis, most of them apoptotic

azoospermia ( J:307409 )

♂

abnormal spermatid morphology ( J:307409 )

♂ • malformed heads in elongating spermatids

♂ • irregular shapes in stage X-XVI spermatids

♂ • abnormal Hematoxylin and Eosin (H&E) staining in spermatid nuclei

♂ • failure of spermatids to undergo proper elongation from stage X-XI

♂ • incomplete chromosomal condensation in elongating spermatids

abnormal spermiogenesis ( J:307409 )

♂ • failure of spermatids to undergo proper elongation from stage X-XI

♂ • incomplete chromosomal condensation in elongating spermatids

increased Sertoli cell phagocytosis ( J:307409 )

♂ • deformed spermatid nuclei engulfed by Sertoli cells

male infertility ( J:307409 )

♂

endocrine/exocrine glands

increased testis apoptosis ( J:307409 )

♂ • 7.2x increase in apoptosis in seminiferous tubules

decreased testis weight ( J:307409 )

♂ • testis plus epididymis weight 14.5% lower

cellular

azoospermia ( J:307409 )

♂

abnormal spermatid morphology ( J:307409 )

♂ • malformed heads in elongating spermatids

♂ • irregular shapes in stage X-XVI spermatids

♂ • abnormal Hematoxylin and Eosin (H&E) staining in spermatid nuclei

♂ • failure of spermatids to undergo proper elongation from stage X-XI

♂ • incomplete chromosomal condensation in elongating spermatids

increased testis apoptosis ( J:307409 )

♂ • 7.2x increase in apoptosis in seminiferous tubules

growth/size/body

growth/size/body region phenotype ( J:307409 )

♂N • normal body weight

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
male infertility		DOID:12336		J:307409