reproductive system
N |
• females are fertile
• normal testis appearance in males
|
• 7.2x increase in apoptosis in seminiferous tubules
|
• testis plus epididymis weight 14.5% lower
|
• virtual lack of sperm in rete testis, efferent ducts, caput, corpus and cauda epididymal lumen
• accumulation of abnormal cells in cauda epididymis, most of them apoptotic
|
azoospermia
(
J:307409
)
|
• malformed heads in elongating spermatids
• irregular shapes in stage X-XVI spermatids
• abnormal Hematoxylin and Eosin (H&E) staining in spermatid nuclei
• failure of spermatids to undergo proper elongation from stage X-XI
• incomplete chromosomal condensation in elongating spermatids
|
• failure of spermatids to undergo proper elongation from stage X-XI
• incomplete chromosomal condensation in elongating spermatids
|
• deformed spermatid nuclei engulfed by Sertoli cells
|
endocrine/exocrine glands
• 7.2x increase in apoptosis in seminiferous tubules
|
• testis plus epididymis weight 14.5% lower
|
cellular
azoospermia
(
J:307409
)
|
• malformed heads in elongating spermatids
• irregular shapes in stage X-XVI spermatids
• abnormal Hematoxylin and Eosin (H&E) staining in spermatid nuclei
• failure of spermatids to undergo proper elongation from stage X-XI
• incomplete chromosomal condensation in elongating spermatids
|
• 7.2x increase in apoptosis in seminiferous tubules
|
growth/size/body
N |
• normal body weight
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
male infertility | DOID:12336 | J:307409 |