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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tsga8em2Ohbo
endonuclease-mediated mutation 2, Kazuyuki Ohbo
MGI:6726554
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tsga8em2Ohbo/Tsga8em2Ohbo C57BL/6-Tsga8em2Ohbo MGI:6727062


Genotype
MGI:6727062
hm1
Allelic
Composition
Tsga8em2Ohbo/Tsga8em2Ohbo
Genetic
Background
C57BL/6-Tsga8em2Ohbo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tsga8em2Ohbo mutation (0 available); any Tsga8 mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• females are fertile
• normal testis appearance in males
• 7.2x increase in apoptosis in seminiferous tubules
• testis plus epididymis weight 14.5% lower
• virtual lack of sperm in rete testis, efferent ducts, caput, corpus and cauda epididymal lumen
• accumulation of abnormal cells in cauda epididymis, most of them apoptotic
• malformed heads in elongating spermatids
• irregular shapes in stage X-XVI spermatids
• abnormal Hematoxylin and Eosin (H&E) staining in spermatid nuclei
• failure of spermatids to undergo proper elongation from stage X-XI
• incomplete chromosomal condensation in elongating spermatids
• failure of spermatids to undergo proper elongation from stage X-XI
• incomplete chromosomal condensation in elongating spermatids
• deformed spermatid nuclei engulfed by Sertoli cells

endocrine/exocrine glands
• 7.2x increase in apoptosis in seminiferous tubules
• testis plus epididymis weight 14.5% lower

cellular
• malformed heads in elongating spermatids
• irregular shapes in stage X-XVI spermatids
• abnormal Hematoxylin and Eosin (H&E) staining in spermatid nuclei
• failure of spermatids to undergo proper elongation from stage X-XI
• incomplete chromosomal condensation in elongating spermatids
• 7.2x increase in apoptosis in seminiferous tubules

growth/size/body
N
• normal body weight

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
male infertility DOID:12336 J:307409





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory