Phenotypes associated with this allele

• Allele Symbol: Trpm3^em1Alsh
• Allele Name: endonuclease-mediated mutation 1, Alan Shiels
• Allele ID: MGI:6727113
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpm3^em1Alsh/Trpm3^em1Alsh	involves: C57BL/6J * CBA	MGI:6727359
ht2	Trpm3^em1Alsh/Trpm3^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6J * CBA	MGI:6727361

Genotype
MGI:6727359

hm1

• Allelic Composition: Trpm3^em1Alsh/Trpm3^em1Alsh
• Genetic Background: involves: C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal iris pigment epithelium ( J:307352 )

• partial adhesion to anterior lens surface

abnormal lens morphology ( J:307352 )

• accumulation of nucleated cells in and around lens from equator to posterior pole

• partial adhesion of iris pigment epithelium to anterior lens surface

• progressive lens fiber cell degeneration

• progressive calcium accumulation

• progressive accumulation of myofibroblast- and macrophage-like cells, especially in anterior pyramidal cataract region

abnormal lens capsule morphology ( J:307352 )

• thickened, folded or wrinkled in anterior pyramidal cataract region

• normal in equatorial region

abnormal lens epithelium morphology ( J:307352 )

• abnormal multi-layering of anterior epithelium

abnormal lens topology ( J:307352 )

• anterior displacement of lens nucleus

anterior polar cataract ( J:307352 )

• fibrotic pyramidal cataract

• progressive calcium accumulation

small lens ( J:307352 )

microphthalmia ( J:307352 )

pigmentation

abnormal iris pigment epithelium ( J:307352 )

• partial adhesion to anterior lens surface

reproductive system

reproductive system phenotype ( J:307352 )

N • fertile

mortality/aging

mortality/aging ( J:307352 )

N • viable

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract		DOID:83	OMIM:601371 OMIM:PS116200	J:307352
microphthalmia		DOID:10629		J:307352

Genotype
MGI:6727361

ht2

• Allelic Composition: Trpm3^em1Alsh/Trpm3^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J * CBA

vision/eye

abnormal iris pigment epithelium ( J:307352 )

• partial adhesion to anterior lens surface

abnormal lens morphology ( J:307352 )

• accumulation of nucleated cells in and around lens from equator to posterior pole

• partial adhesion of iris pigment epithelium to anterior lens surface

• progressive lens fiber cell degeneration

• progressive calcium accumulation

• progressive accumulation of myofibroblast- and macrophage-like cells, especially in anterior pyramidal cataract region

abnormal lens capsule morphology ( J:307352 )

• thickened, folded or wrinkled in anterior pyramidal cataract region

• normal in equatorial region

abnormal lens epithelium morphology ( J:307352 )

• abnormal multi-layering of anterior epithelium

abnormal lens topology ( J:307352 )

• anterior displacement of lens nucleus

anterior polar cataract ( J:307352 )

• fibrotic pyramidal cataract

• progressive calcium accumulation

small lens ( J:307352 )

microphthalmia ( J:307352 )

pigmentation

abnormal iris pigment epithelium ( J:307352 )

• partial adhesion to anterior lens surface

reproductive system

reproductive system phenotype ( J:307352 )

• fertile

mortality/aging

mortality/aging ( J:307352 )

• viable

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract		DOID:83	OMIM:601371 OMIM:PS116200	J:307352
microphthalmia		DOID:10629		J:307352