Phenotypes associated with this allele

• Allele Symbol: Gm614^tm1.1Cya
• Allele Name: targeted mutation 1.1, Cyagen Biosciences
• Allele ID: MGI:6727377
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gm614^tm1.1Cya/Gm614^tm1.1Cya Ighg1^tm1(cre)Cgn/Ighg1^+	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N	MGI:6727909

Genotype
MGI:6727909

cn1

• Allelic Composition: Gm614^tm1.1Cya/Gm614^tm1.1Cya; Ighg1^tm1(cre)Cgn/Ighg1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:307345 )

N • normal total IgG levels after pristane injection

N • normal CD86^loCXCR4^hi dark zone (DZ) and CD86^hiCXCR4^lo light zone (LZ) B cells ratio after pristane injection

N • normal B cell cell cycle after pristane injection

increased B cell apoptosis ( J:307345 )

• in germinal center after pristane injection

decreased susceptibility to systemic lupus erythematosus ( J:307345 )

• reduced inflammatory cell infiltration in kidney and normal glomerular morphology after pristane injection

• reduced levels of IgM and IgG anti-nucleic antibodies and anti-nucleosome IgG after pristane injection

hematopoietic system

increased B cell apoptosis ( J:307345 )

• in germinal center after pristane injection

cellular

increased B cell apoptosis ( J:307345 )

• in germinal center after pristane injection