About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Txndc5em1Ntuh
endonuclease-mediated mutation 1, National Taiwan University Hospital
MGI:6728079
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Txndc5em1Ntuh/Txndc5em1Ntuh C57BL/6J-Txndc5em1Ntuh MGI:6728089


Genotype
MGI:6728089
hm1
Allelic
Composition		 Txndc5em1Ntuh/Txndc5em1Ntuh
Genetic
Background		 C57BL/6J-Txndc5em1Ntuh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Txndc5em1Ntuh mutation (0 available); any Txndc5 mutation (26 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiac fibrosis ( J:307898 )
• minimal in response to isoproterenol treatment
abnormal myocardial fiber physiology ( J:307898 )
• reduced proliferative activity in response to TGFbeta1 stimulation
decreased response of heart to induced stress ( J:307898 )
• isoproterenol-treated mice exhibit no increased heart weight and reduced cardiac fibrosis and myocardial dysfunction compared with wild-type mice

homeostasis/metabolism
decreased response of heart to induced stress ( J:307898 )
• isoproterenol-treated mice exhibit no increased heart weight and reduced cardiac fibrosis and myocardial dysfunction compared with wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory