Phenotypes associated with this allele

• Allele Symbol: Myl9^tm1Mzhu
• Allele Name: targeted mutation 1, Min-Sheng Zhu
• Allele ID: MGI:6728817
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Myl9^tm1Mzhu/Myl9^tm1Mzhu Tg(Acta2-cre)#Xya/0	involves: C57BL/6 * CBA	MGI:6728833

Genotype
MGI:6728833

cn1

• Allelic Composition: Myl9^tm1Mzhu/Myl9^tm1Mzhu; Tg(Acta2-cre)#Xya/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:308237 )

• all mice die around P28

muscle

abnormal aorta smooth muscle morphology ( J:308237 )

• thin smooth muscle layer in the aorta

abnormal vascular smooth muscle physiology ( J:308237 )

• decreased maximal force evoked by depolarization and agonist treatment (U46619)

abnormal intestinal peristalsis ( J:308237 )

• impaired peristaltic amplitude in the jejunum

• however, peristaltic frequencies are normal

impaired smooth muscle contractility ( J:308237 )

• failure of acetylcholine to initiate and sustain contraction in jejunum smooth muscle

• decreased maximal force evoked by depolarization and agonist treatment (U46619)

• bladder smooth muscle exhibit inhibited initial phase, but normal sustained phase

impaired contractility of jejunal smooth muscle ( J:308237 )

• smaller force generation from jejunum smooth muscle than in control mice

• failure of acetylcholine to initiate and sustain contraction in jejunum smooth muscle

• impaired peristaltic amplitude, but not frequencies

digestive/alimentary system

distended duodenum ( J:308237 )

• dilated with abundant liquid

abnormal jejunum morphology ( J:308237 )

• increased smooth muscle thickness

distended jejunum ( J:308237 )

• dilated with abundant liquid

abnormal intestinal peristalsis ( J:308237 )

• impaired peristaltic amplitude in the jejunum

• however, peristaltic frequencies are normal

cardiovascular system

abnormal aorta smooth muscle morphology ( J:308237 )

• thin smooth muscle layer in the aorta

abnormal vascular smooth muscle physiology ( J:308237 )

• decreased maximal force evoked by depolarization and agonist treatment (U46619)

liver/biliary system

dark liver ( J:308237 )

• darker than in control mice