Analysis Tools
behavior/neurological
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• in open field test, the number of line crossings transitions between the external and internal zones was significantly higher in the Spock3- mutant mice than in the WT mice
• no significant differences between the WT and mutant mice in the total distances traveled or in the time spent in the internal zone
• in the elevated plus-maze test, there were no significant differences between WT and mutant mice in the time spent in the open- and closed-arm areas
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• in a three-chambered social interaction test, Spock3- mutant mice have markedly decreased preference to social nov
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nervous system
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• showed an overt alternation of the brain shape, resulting in a more rostrocaudally elongated brain morphology than that of the WT mice
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• the fasciculation of the corpus callosum in the Spock3- mutant mice was abnormal compared to the WT counterparts. Many unstained or weakly stained spots were identified in the corpus callosum of Spock3- mutant mice
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• the corpus callosum of the Spock3 -mutant mice was narrower in some planes (bregma 0.7 mm ) than in the WT mice
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• the thickness of the cerebral neocortex increased to 129%
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• the axonal fasciculation of afferent/efferent fibers of the cerebral cortex was impaired
• the thin fibers at the top of the corpus callosum and thick fibers entering the striatum were only sparsely present
• long axon bundles were scarcely observed in the dorsal striatum of the Spock3 mutants
• the number of axonal bundles in the striatum appeared to be less than in WT mice
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• the neuron densities of each cortical layer were reduced in the mutant mice
• The cell nuclei present in the white matter of the mutant mice, the oligodendrocyte cell nuclei, were identical to those in their WT counterparts
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• in the cerebral cortices of the Spock3- mutant mice, the neurons that occupied each layer were larger
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