Phenotypes associated with this allele

• Allele Symbol: C1qtnf4^em1Smoc
• Allele Name: endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• Allele ID: MGI:6729707
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	C1qtnf4^em1Smoc/C1qtnf4^em1Smoc	C57BL/6J-C1qtnf4^em1Smoc/Smoc	MGI:6729709

Genotype
MGI:6729709

hm1

• Allelic Composition: C1qtnf4^em1Smoc/C1qtnf4^em1Smoc
• Genetic Background: C57BL/6J-C1qtnf4^em1Smoc/Smoc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:302282 )

• no mice treated with LPS survive beyond 60 hr

immune system

abnormal macrophage differentiation ( J:302282 )

• LPS or IL4-stimulated macrophages exhibit M1 phenotype polarization

increased circulating interleukin-18 level ( J:302282 )

• after LPS treatment

increased circulating interleukin-6 level ( J:302282 )

• 3-fold 6 hr after LPS treatment

increased circulating tumor necrosis factor level ( J:302282 )

• after LPS treatment

increased tumor necrosis factor secretion ( J:302282 )

• after LPS treatment

increased susceptibility to endotoxin shock ( J:302282 )

• mice treated with LPS treatment exhibit increased IL6, TNFalpha, and IFNgamma serum levels, increased macrophage production of TNFalpha, increased lung inflammation, and no survival at 60 hr compared with wild-type mice

homeostasis/metabolism

increased circulating interleukin-18 level ( J:302282 )

• after LPS treatment

increased circulating interleukin-6 level ( J:302282 )

• 3-fold 6 hr after LPS treatment

increased circulating tumor necrosis factor level ( J:302282 )

• after LPS treatment

hematopoietic system

abnormal macrophage differentiation ( J:302282 )

• LPS or IL4-stimulated macrophages exhibit M1 phenotype polarization

cellular

abnormal macrophage differentiation ( J:302282 )

• LPS or IL4-stimulated macrophages exhibit M1 phenotype polarization