All Phenotypes Lyz2<em1(icre)Gpt> MGI Mouse

Phenotypes associated with this allele

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:330879 )

immune system

immune system phenotype ( J:330879 )

N	• in vitro differentiation of bone marrow derived dendritic cells and bone marrow derived macrophages is normal

decreased circulating interferon-beta level ( J:330879 )

• in HSV-1-infected mice

decreased circulating interleukin-6 level ( J:330879 )

• in HSV-1-infected mice

decreased interferon-beta secretion ( J:330879 )

• in bone marrow derived dendritic cells exposed to HSV-1 or cytoplasmic DNA

• however, bone marrow derived dendritic cells exhibit normal production of IFN-beta in response to SeV-, poly(I:C)-, or cGAMP

decreased interleukin-6 secretion ( J:330879 )

• in bone marrow derived dendritic cells exposed to HSV-1 or cytoplasmic DNA

• however, bone marrow derived dendritic cells exhibit normal production of IL6 in response to SeV-, poly(I:C)-, or cGAMP

increased susceptibility to Herpesvirales infection ( J:330879 )

• bone marrow derived dendritic cells exposed to HSV-1 or cytoplasmic DNA produce less IFN-beta and IL6

• HSV-1-infected mice exhibit increased viral titer in the brain, decreased IFN-beta and IL6 sera levels, and increased mortality compared with control mice

• however, bone marrow derived dendritic cells exhibit normal production of IFN-beta and IL6 in response to SeV-, poly(I:C)-, or cGAMP

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:330879 )

homeostasis/metabolism

decreased circulating interferon-beta level ( J:330879 )

• in HSV-1-infected mice

decreased circulating interleukin-6 level ( J:330879 )

• in HSV-1-infected mice

Allelic Composition	Arih1^em3Gpt/Arih1^em3Gpt Lyz2^em1(icre)Gpt/Lyz2⁺ Trex1^em1Gpt/Trex1^em1Gpt
Genetic Background	C57BL/6JGpt-Arih1^em3Gpt Trex1^em1Gpt Lyz2^em1(icre)Gpt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arih1^em3Gpt mutation (0 available); any Arih1 mutation (33 available)
Lyz2^em1(icre)Gpt mutation (0 available); any Lyz2 mutation (40 available)
Trex1^em1Gpt mutation (0 available); any Trex1 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:330879 )

N	• unlike Trex1^em1Gpt homozygotes, mice exhibit normal survival

immune system

immune system phenotype ( J:330879 )

N	• unlike Trex1^em1Gpt homozygotes, mice exhibit normalized spleen size and weight; serum levels of TNF, CXCL1, CCL5, and total IgG; and autoimmune phenotypes

growth/size/body

growth/size/body region phenotype ( J:330879 )

N	• unlike Trex1^em1Gpt homozygotes, mice exhibit normalized development and body weight

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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