Phenotypes associated with this allele

• Allele Symbol: Lyz2^em1(icre)Gpt
• Allele Name: endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• Allele ID: MGI:6729910
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Arih1^em3Gpt/Arih1^em3Gpt Lyz2^em1(icre)Gpt/Lyz2^+	C57BL/6JGpt-Arih1^em3Gpt Lyz2^em1(icre)Gpt	MGI:7410887
cn2	Arih1^em3Gpt/Arih1^em3Gpt Lyz2^em1(icre)Gpt/Lyz2^+ Trex1^em1Gpt/Trex1^em1Gpt	C57BL/6JGpt-Arih1^em3Gpt Trex1^em1Gpt Lyz2^em1(icre)Gpt	MGI:7410894

Genotype
MGI:7410887

cn1

• Allelic Composition: Arih1^em3Gpt/Arih1^em3Gpt; Lyz2^em1(icre)Gpt/Lyz2⁺
• Genetic Background: C57BL/6JGpt-Arih1^em3Gpt Lyz2^em1(icre)Gpt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:330879 )

immune system

immune system phenotype ( J:330879 )

N • in vitro differentiation of bone marrow derived dendritic cells and bone marrow derived macrophages is normal

decreased circulating interferon-beta level ( J:330879 )

• in HSV-1-infected mice

decreased circulating interleukin-6 level ( J:330879 )

• in HSV-1-infected mice

decreased interferon-beta secretion ( J:330879 )

• in bone marrow derived dendritic cells exposed to HSV-1 or cytoplasmic DNA

• however, bone marrow derived dendritic cells exhibit normal production of IFN-beta in response to SeV-, poly(I:C)-, or cGAMP

decreased interleukin-6 secretion ( J:330879 )

• in bone marrow derived dendritic cells exposed to HSV-1 or cytoplasmic DNA

• however, bone marrow derived dendritic cells exhibit normal production of IL6 in response to SeV-, poly(I:C)-, or cGAMP

increased susceptibility to Herpesvirales infection ( J:330879 )

• bone marrow derived dendritic cells exposed to HSV-1 or cytoplasmic DNA produce less IFN-beta and IL6

• HSV-1-infected mice exhibit increased viral titer in the brain, decreased IFN-beta and IL6 sera levels, and increased mortality compared with control mice

• however, bone marrow derived dendritic cells exhibit normal production of IFN-beta and IL6 in response to SeV-, poly(I:C)-, or cGAMP

increased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:330879 )

homeostasis/metabolism

decreased circulating interferon-beta level ( J:330879 )

• in HSV-1-infected mice

decreased circulating interleukin-6 level ( J:330879 )

• in HSV-1-infected mice

Genotype
MGI:7410894

cn2

• Allelic Composition: Arih1^em3Gpt/Arih1^em3Gpt; Lyz2^em1(icre)Gpt/Lyz2⁺; Trex1^em1Gpt/Trex1^em1Gpt
• Genetic Background: C57BL/6JGpt-Arih1^em3Gpt Trex1^em1Gpt Lyz2^em1(icre)Gpt

mortality/aging

mortality/aging ( J:330879 )

N • unlike Trex1^em1Gpt homozygotes, mice exhibit normal survival

immune system

immune system phenotype ( J:330879 )

N • unlike Trex1^em1Gpt homozygotes, mice exhibit normalized spleen size and weight; serum levels of TNF, CXCL1, CCL5, and total IgG; and autoimmune phenotypes

growth/size/body

growth/size/body region phenotype ( J:330879 )

N • unlike Trex1^em1Gpt homozygotes, mice exhibit normalized development and body weight