Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-Pgam2)#Hiko
• Allele Name: transgene insertion, Hiroshi Kondoh
• Allele ID: MGI:6730133
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(CAG-Pgam2)#Hiko/0	involves: C57BL/6	MGI:6731048

Genotype
MGI:6731048

tg1

• Allelic Composition: Tg(CAG-Pgam2)#Hiko/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

increased susceptibility to chemically induced skin inflammation ( J:306793 )

• skin is more vulnerable to inflammation caused by the proinflammatory agent 12-O-tetradecanoylphorbol-13-acetate (TPA)

neoplasm

increased incidence of tumors by chemical induction ( J:306793 )

• mice treated with 7,12-dimethylbenz[a]anthracene (DMBA) followed by TPA show an increase in total tumor numbers and in tumor size; some of the largest tumors are accompanied by moderate-to-severe ulceration

• 3 of 25 tumors in DMBA- and TPA-treated mice show characteristics of squamous cell carcinoma (dyskeratosis, numerous mitoses, severe disturbances of stratification) compared to control mice in which all tumors are benign squamous cell papillomas

immune system

increased susceptibility to chemically induced skin inflammation ( J:306793 )

• skin is more vulnerable to inflammation caused by the proinflammatory agent 12-O-tetradecanoylphorbol-13-acetate (TPA)

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:307317 )

N • mice exhibit normal glucose metabolism, weight, and high-fat induced obesity

increased incidence of tumors by chemical induction ( J:306793 )

• mice treated with 7,12-dimethylbenz[a]anthracene (DMBA) followed by TPA show an increase in total tumor numbers and in tumor size; some of the largest tumors are accompanied by moderate-to-severe ulceration

• 3 of 25 tumors in DMBA- and TPA-treated mice show characteristics of squamous cell carcinoma (dyskeratosis, numerous mitoses, severe disturbances of stratification) compared to control mice in which all tumors are benign squamous cell papillomas