Phenotypes associated with this allele

• Allele Symbol: Pten^tm1.1Yxy
• Allele Name: targeted mutation 1.1, Yuxin Yin
• Allele ID: MGI:6730304
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pten^tm1.1Yxy/Pten^tm1.1Yxy	involves: C57BL/6	MGI:6731043

Genotype
MGI:6731043

hm1

• Allelic Composition: Pten^tm1.1Yxy/Pten^tm1.1Yxy
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

taste/olfaction

impaired olfaction ( J:290673 )

• significantly increased food-finding latency in buried food pellet test

• reduced odor sensitivity

• normal ability to discriminate different odors in odor habituation-dishabituation test

muscle

increased myocardial fiber mitochondrial DNA content ( J:308567 )

• increased mitochondrial DNA content in cardiomyocytes from age 4 months

cardiovascular system

cardiovascular system phenotype ( J:308567 )

N • normal heart morphology and function under basal conditions

increased myocardial fiber mitochondrial DNA content ( J:308567 )

• increased mitochondrial DNA content in cardiomyocytes from age 4 months

increased susceptibility to myocardial ischemic injury ( J:308567 )

• more severe cardiac ischemia-reperfusion (I-R) injury: more necrotic tissue

• higher percentage of cardiomyocytes with decreased mitochondrial electrochemical potential after cardiac ischemia-reperfusion (I-R)

increased myocardial infarct size ( J:308567 )

• more necrotic tissue and lager infarct size after cardiac ischemia-reperfusion (I-R)

behavior/neurological

behavior/neurological phenotype ( J:256248 )

N • normal locomotor activity and emotional behavior

impaired spatial learning ( J:256248 )

• no decrease in latency to find hidden platform and no increase in time spent in target quadrant of removed platform in Morris water maze test

fast extinction of fear memory ( J:256248 )

• impaired contextual fear memory recall

cellular

cellular phenotype ( J:290673 , J:308567 )

N • normal level of reactive oxygen species in olfactory bulb (J:290673)

N • normal mitochondrial electrochemical potential under basal conditions (J:308567)

abnormal mitochondrial morphology ( J:308567 )

• increased percentage of abnormal mitochondria and mitochondrial content in cardiomyocytes from age 4 months

• normal mitochondria in cardiomyocytes at age 2 months

• normal mitochondrial size in cardiomyocytes from age 4 months

increased myocardial fiber mitochondrial DNA content ( J:308567 )

• increased mitochondrial DNA content in cardiomyocytes from age 4 months

disorganized mitochondrial cristae ( J:308567 )

• disorganized and partially lost cristae in cardiomyocytes from age 4 months

abnormal mitophagy ( J:308567 )

• impaired PARK2-ubiquitin dependent mitophagy in cardiomyocytes from age 4 months

abnormal cellular respiration ( J:308567 )

• decreased basal and maximal respiration in cardiomyocytes

abnormal endocytosis ( J:290673 )

• impaired endocytosis in olfactory bulb neurons

growth/size/body

growth/size/body region phenotype ( J:256248 )

N • normal body weight and gross morphology

homeostasis/metabolism

increased susceptibility to myocardial ischemic injury ( J:308567 )

• more severe cardiac ischemia-reperfusion (I-R) injury: more necrotic tissue

• higher percentage of cardiomyocytes with decreased mitochondrial electrochemical potential after cardiac ischemia-reperfusion (I-R)

increased myocardial infarct size ( J:308567 )

• more necrotic tissue and lager infarct size after cardiac ischemia-reperfusion (I-R)

abnormal mitophagy ( J:308567 )

• impaired PARK2-ubiquitin dependent mitophagy in cardiomyocytes from age 4 months

increased glutamic acid level ( J:290673 )

• increased glutamate levels and glutamate:GABA ratio in olfactory bulb

nervous system

nervous system phenotype ( J:256248 , J:290673 )

N • normal excitatory postsynaptic potentials (EPSPs) in acute hippocampal slices (J:256248)

N • normal paired pulse facilitation over a range of inter-pulse intervals in hippocampus (J:256248)

N • normal hippocampus and cortex morphology (J:256248)

N • normal gross morphology of olfactory bulb (J:290673)

N • normal number of TH-positive short axon interneurons in periglomerular layer of olfactory bulb (J:290673)

N • normal number of astrocytes in olfactory bulb (J:290673)

N • normal cell proliferation in subventricular zone (SVZ) (J:290673)

abnormal olfactory bulb development ( J:290673 )

• reduced cell proliferation

abnormal olfactory bulb mitral cell layer morphology ( J:290673 )

• decreased number of mitral cells

abnormal glutamate-mediated receptor currents ( J:256248 )

• significantly increased AMPA/NMDA current ratio in hippocampus

reduced long-term potentiation ( J:256248 )

• after induction in Schaffer collateral pathway using a high-frequency train (100 Hz for 1 s)

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:308567 )

• more severe cardiac hypertrophy (higher heart weight to body weight ratio and greater cardiomyocyte cross-sectional area) 7 days after i.p. injection of isoprenaline (ISO)

• greater decrease in fractional shortening 7 days after i.p. injection of isoprenaline (ISO)

• more interstitial cardiac fibrosis 7 days after i.p. injection of isoprenaline (ISO)

reproductive system

reproductive system phenotype ( J:256248 )

N • normal fertility and birthrate