All Phenotypes Zfp217<em1Sjia> MGI Mouse

decreased susceptibility to diet-induced obesity ( J:307358 )

• mice are resistant to diet-induced obesity, with mice showing slower weight gain on a high-fat diet

• however, mice do not show a difference in food intake on a high-fat diet or in weight on a chow diet

abnormal adipose tissue development ( J:307358 )

• mouse embryo fibroblasts (MEFs) induced in an adipogenic culture medium to differentiate into adipocytes show fewer lipid droplets and lower triglyceride content indicating decreased adipogenic potential and marker analysis indicates reduced adipogenesis

decreased fat cell size ( J:307358 )

• mice fed a high-fat diet show a smaller average area and size distribution of adipocytes

decreased total fat pad weight ( J:307358 )

• high-fat diet fed mice have lower fat weight and smaller iWAT and BAT pads

• however, no differences in eWAT pads is seen on a high-fat diet

decreased percent body fat/body weight ( J:307358 )

• high-fat diet fed mice have lower percentage total body fat

• however, mice fed a chow diet show normal percentage total body fat

increased energy expenditure ( J:307358 )

• mice exhibit increased energy expenditure in dark phases when fed a chow diet

• energy expenditure rate is increased during both light and dark phases in high-fat diet fed mice

decreased susceptibility to diet-induced obesity ( J:307358 )

• mice are resistant to diet-induced obesity, with mice showing slower weight gain on a high-fat diet

• however, mice do not show a difference in food intake on a high-fat diet or in weight on a chow diet

increased carbon dioxide production ( J:307358 )

• total volume of carbon dioxide production (VCO2) is increased in high-fat diet fed mice during both light and dark phases

increased oxygen consumption ( J:307358 )

• mice exhibit increased oxygen consumption (VO2) in dark phases when fed a chow diet

• oxygen consumption is increased in high-fat diet fed mice during both light and dark phases

improved glucose tolerance ( J:307358 )

• glucose tolerance test shows that mice fed a high-fat diet exhibit improved glucose clearance

• however, mouse fed a chow diet show no differences in glucose tolerance from wild-type mice

increased insulin sensitivity ( J:307358 )

• insulin tolerance test shows that mice fed a high-fat diet are more sensitive to insulin than willd-type mice

• however, mouse fed a chow diet show no differences in insulin tolerance from wild-type mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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