Phenotypes associated with this allele

• Allele Symbol: Zfp622^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6731067
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp622^em1(IMPC)J/Zfp622^em1(IMPC)J	C57BL/6NJ-Zfp622^em1(IMPC)J/Mmjax	MGI:7472335

Genotype
MGI:7472335

hm1

• Allelic Composition: Zfp622^em1(IMPC)J/Zfp622^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Zfp622^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Zfp622

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Zfp622^em1(IMPC)J/Zfp622^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 but not at E7.5. Embryos at E3.5 appear as dying morulae. Mutants fail to hatch from the zona pellucida and never reach blastocyst stage in culture.

embryo

failure of blastocyst formation ( J:279207 )

• in vitro, embryos fail to form blastocysts and are dead after 3 days in culture

failure of blastocyst to hatch from the zona pellucida ( J:279207 )

• in vitro, embryos fail to hatch from the zona pellucida after 3 days in culture, never forming blastocysts

abnormal morula morphology ( J:279207 )

• embryos recovered at E3.5 appear as dying morulae

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality before implantation, complete penetrance ( J:279207 )

• homozygous embryos are recovered at E3.5 (11% versus expected 25%, n=19) and appear as dying morulae; no homozygous embryos or excess resorption sites are observed at E7.5