Phenotypes associated with this allele

• Allele Symbol: Ppp2r2d^em1Gct
• Allele Name: endonuclease-mediated mutation 1, George C Tsokos
• Allele ID: MGI:6731086
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ppp2r2d^em1Gct/Ppp2r2d^em1Gct Tg(Lck-icre)3779Nik/0	involves: C57BL/6 * DBA/2	MGI:6740222

Genotype
MGI:6740222

cn1

• Allelic Composition: Ppp2r2d^em1Gct/Ppp2r2d^em1Gct; Tg(Lck-icre)3779Nik/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:308373 )

N • normal T cell subset percentages and absolute numbers in thymus and spleen

N • normal percentage of apoptotic double-negative and double-positive thymocytes after CD3 antibody stimulation

abnormal regulatory T cell physiology ( J:308373 )

• increased suppressive activity

immune system

abnormal regulatory T cell physiology ( J:308373 )

• increased suppressive activity

increased interleukin-2 secretion ( J:308373 )

• increased production in stimulated spleen CD4+ and CD8+ T cells

behavior/neurological

behavior/neurological phenotype ( J:308373 )

N • normal behavior

growth/size/body

growth/size/body region phenotype ( J:308373 )

N • normal size, no gross abnormalities

mortality/aging

mortality/aging ( J:308373 )

N • viable

reproductive system

reproductive system phenotype ( J:308373 )

N • fertile