Phenotypes associated with this allele

• Allele Symbol: Mb^em1Shad
• Allele Name: endonuclease-mediated mutation 1, Sean H Adams
• Allele ID: MGI:6752552
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mb^em1Shad/Mb^em1Shad	B6N-Mb^em1Shad	MGI:6753229

Genotype
MGI:6753229

hm1

• Allelic Composition: Mb^em1Shad/Mb^em1Shad
• Genetic Background: B6N-Mb^em1Shad

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased capillary density ( J:307655 , J:307655 , J:307655 )

• normal in extensor digitorum longus (EDL) and plantaris muscles (J:307655)

• increased ratio of capillaries to muscle fibers in gastrocnemius and soleus (J:307655)

♀ • reduced heart capillarity (J:307655)

♂ • increased heart capillarity (J:307655)

behavior/neurological

behavior/neurological phenotype ( J:307655 )

N • normal X-axis (length of cage) ambulatory and Z-axis activity at age 5-6 weeks

abnormal locomotor behavior ( J:307655 , J:307655 , J:307655 )

• normal X-axis (length of cage) ambulatory activity at age 5-6 weeks (J:307655)

♀ • reduced total X-axis beam breaks per 24h at age 11-12 weeks, irrespective of temperature (J:307655)

♂ • reduced total X-axis beam breaks per 24h at age 17-18 weeks, irrespective of temperature (J:307655)

growth/size/body

growth/size/body region phenotype ( J:307655 )

N • normal body weight when fed high-fat diet (HFD)

N • normal tissue and organ weights and total fat mass when fed HFD

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:307655 )

N • normal food or energy intake when fed high-fat diet (HFD)

N • normal glucose tolerance and insulin-associated blood glucose reduction when fed HFD

N • normal respiratory quotient (respiratory exchange ratio; RER) irrespective of age, diet or temperature

N • normal energy expenditure, irrespective of age, sex, diet or temperature

muscle

muscle phenotype ( J:307655 )

N • normal muscle mass when fed high-fat diet (HFD)

N • normal mean fiber area in in gastrocnemius, soleus, extensor digitorum longus (EDL) and plantaris muscles