Phenotypes associated with this allele

• Allele Symbol: Rr27^tm1.1Mnn
• Allele Name: targeted mutation 1.1, Jeffrey R Mann
• Allele ID: MGI:6753234
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Rr27^tm1.1Mnn/Rr27^+	involves: 129S1/Sv * CAST/Ei * FVB/NJ * Swiss	MGI:6753271

Genotype
MGI:6753271

ht1

• Allelic Composition: Rr27^tm1.1Mnn/Rr27⁺
• Genetic Background: involves: 129S1/Sv * CAST/Ei * FVB/NJ * Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal imprinting ( J:308869 )

• defective paternal imprinting: failure to activate Igf2 expression and suppress of H19 expression on paternal allele

• normal maternal imprinting: suppression of Igf2 expression and activation of H19 expression on maternal allele

embryo

decreased embryo weight ( J:308869 )

• small (50-61% of normal weight) but normally proportioned E18.5 embryos when inheriting paternal allele

• normal when inheriting maternal allele

growth/size/body

decreased embryo weight ( J:308869 )

• small (50-61% of normal weight) but normally proportioned E18.5 embryos when inheriting paternal allele

• normal when inheriting maternal allele

decreased birth body size ( J:308869 )

• small but normally proportioned body when inheriting paternal allele

• normal when inheriting maternal allele

mortality/aging

mortality/aging ( J:308869 )

N • viable, irrespective of maternal/paternal inheritance of allele