About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fis1tm1Dcc
targeted mutation 1, David C Chan
MGI:6755477
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Fis1tm1Dcc/Fis1tm1.1Dcc
Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+
Tg(Stra8-icre)1Reb/0 		involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ MGI:6755500


Genotype
MGI:6755500
cn1
Allelic
Composition		 Fis1tm1Dcc/Fis1tm1.1Dcc
Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc/Gt(ROSA)26Sor+
Tg(Stra8-icre)1Reb/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fis1tm1.1Dcc mutation (0 available); any Fis1 mutation (47 available)
Fis1tm1Dcc mutation (0 available); any Fis1 mutation (47 available)
Gt(ROSA)26Sortm1.1(CAG-COX8A/Dendra2)Dcc mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Stra8-icre)1Reb mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
azoospermia ( J:309044 )
• no spermatozoa in epididymides
abnormal spermatid morphology ( J:309044 )
• impaired acrosome development and failure to produce elongated spermatids
multinucleated giant male germ cells ( J:309044 )
• with increased mitochondria content
increased male germ cell apoptosis ( J:309044 )
• 4-fold increase in tubules

cellular
azoospermia ( J:309044 )
• no spermatozoa in epididymides
abnormal spermatid morphology ( J:309044 )
• impaired acrosome development and failure to produce elongated spermatids
multinucleated giant male germ cells ( J:309044 )
• with increased mitochondria content
increased mitochondrial number ( J:309044 )
• in round spermatids and giant cells
impaired autophagy ( J:309044 )
• in round spermatids and giant cells with aberrant accumulation of autophagic structures
increased male germ cell apoptosis ( J:309044 )
• 4-fold increase in tubules

homeostasis/metabolism
impaired autophagy ( J:309044 )
• in round spermatids and giant cells with aberrant accumulation of autophagic structures

endocrine/exocrine glands




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory